PMID- 7988747
OWN - NLM
STAT- MEDLINE
DCOM- 19950110
LR  - 20190813
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 104
IP  - 2
DP  - 1994 Sep
TI  - Retinoids are positive effectors of adipose cell differentiation.
PG  - 201-11
AB  - Retinoids, especially all-trans retinoic acid (t-RA), have been reported in the 
      last decade to inhibit the differentiation of preadipose cells. In those studies, 
      however, the concentrations of t-RA were supraphysiological (0.1-10 microM 
      range). In contrast we show that, when present at concentrations below or close 
      to the Kd values of retinoic acid receptors, retinoids behave as potent 
      adipogenic hormones (1 pM to 10 nM range). As shown by the use of specific 
      ligands for each RAR subtype, these positive effects on adipose differentiation 
      involve in particular the RAR alpha subtype, and have been observed in Ob17 cells 
      exposed to serum-supplemented or serum-free medium, and in rat preadipocytes 
      exposed to serum-free medium. Among the two classes of retinoid acid receptors 
      (RARs) and retinoid X receptors (RXRs), RAR alpha, RAR gamma, RXR alpha and RXR 
      beta mRNAs could be detected in growing adipoblasts and were found to be 
      increased in committed preadipocytes and differentiated cells upon retinoid 
      treatment. Like other adipogenic hormones, retinoids were only effective in the 
      terminal differentiation process leading from preadipocytes to adipocytes.
FAU - Safonova, I
AU  - Safonova I
AD  - Centre de Biochimie (UMR 134 CNRS), Universite de Nice-Sophia Antipolis, Faculte 
      des Sciences, France.
FAU - Darimont, C
AU  - Darimont C
FAU - Amri, E Z
AU  - Amri EZ
FAU - Grimaldi, P
AU  - Grimaldi P
FAU - Ailhaud, G
AU  - Ailhaud G
FAU - Reichert, U
AU  - Reichert U
FAU - Shroot, B
AU  - Shroot B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 1.1.- (Glycerolphosphate Dehydrogenase)
SB  - IM
MH  - Adipocytes/cytology/*drug effects
MH  - Animals
MH  - Blotting, Northern
MH  - Cell Differentiation/*drug effects
MH  - Cells, Cultured
MH  - Gene Expression
MH  - Glycerolphosphate Dehydrogenase/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - RNA, Messenger/metabolism
MH  - Receptors, Retinoic Acid/agonists/genetics/metabolism
MH  - Retinoid X Receptors
MH  - Retinoids/*pharmacology
MH  - Transcription Factors/genetics/metabolism
MH  - Tretinoin/pharmacology
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 10.1016/0303-7207(94)90123-6 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 1994 Sep;104(2):201-11. doi: 10.1016/0303-7207(94)90123-6.