PMID- 7988949
OWN - NLM
STAT- MEDLINE
DCOM- 19950106
LR  - 20180216
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 24
IP  - 3
DP  - 1994 May-Jun
TI  - Experimental models for antiphospholipid studies.
PG  - 204-7
AB  - Three types of Experimental Animal Models have been used to investigate APA. 1) 
      Passive transfer of APA to nocive mice. Branch et al injected pregnant Balb/c 
      mice with purified IgG APA from patients with recurrent fetal loss. 2) Active 
      immunization with APA. Backimer et al immunized Balb/c mice with a human 
      monoclonal APA carrying the pathogenic idiotypes. 3) Immunization with beta 2 
      glycoprotein I (beta 2 GPI) (APA cofactor). Using affinity chromatography, we 
      separated two distinct populations of antibodies. One was specific for beta 2GPI 
      without binding to PL. Another population had a dual specificity for PL and beta 
      2GPI.
FAU - Gharavi, A E
AU  - Gharavi AE
AD  - LSU Medical Center, New Orleans 70112.
FAU - Aron, A L
AU  - Aron AL
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Idiotypes)
RN  - 0 (Phospholipids)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
GS  - lpr
MH  - Abortion, Habitual/blood/etiology/immunology
MH  - Animals
MH  - Antibodies, Antiphospholipid/*immunology
MH  - Antibodies, Monoclonal/immunology
MH  - Antiphospholipid Syndrome/complications/immunology
MH  - Autoimmune Diseases/complications/immunology
MH  - Chromatography, Affinity
MH  - *Disease Models, Animal
MH  - Female
MH  - Fetal Resorption/immunology
MH  - Glycoproteins/immunology
MH  - Immunization, Passive
MH  - Immunoglobulin G/immunology
MH  - Immunoglobulin Idiotypes/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred NZB
MH  - Phospholipids/immunology
MH  - Pregnancy
MH  - Rabbits
MH  - Vaccination
MH  - beta 2-Glycoprotein I
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1159/000217102 [doi]
PST - ppublish
SO  - Haemostasis. 1994 May-Jun;24(3):204-7. doi: 10.1159/000217102.