PMID- 7990700
OWN - NLM
STAT- MEDLINE
DCOM- 19950112
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 43
IP  - 12
DP  - 1994 Dec
TI  - Hypocaloric high-protein diet improves glucose oxidation and spares lean body 
      mass: comparison to hypocaloric high-carbohydrate diet.
PG  - 1481-7
AB  - The aim of the study was to investigate the effects of two hypocaloric (800-kcal) 
      diets on body weight reduction and composition, insulin sensitivity, and 
      proteolysis in 25 normal glucose-tolerant obese women. The two diets had the 
      following composition: 45% protein, 35% carbohydrate (CHO), and 20% fat (HP diet, 
      10 subjects), and 60% CHO, 20% protein, and 20% fat (HC diet, 15 subjects); both 
      lasted 21 days. A euglycemic hyperinsulinemic (25 mU/kg/h) clamp lasting 150 
      minutes combined with indirect calorimetry was performed before and after the 
      diet. Both diets induced a similar decrease in body weight and fat mass (FM), 
      whereas fat-free mass (FFM) decreased only after the HC diet. 3-Methylhistidine 
      (3-CH3-HIS) excretion was reduced by 48% after the HP diet and remained unchanged 
      after the HC diet (P < .05). A significant correlation was found between the 
      changes in FFM and in 3-CH3-HIS excretion after the diet (rs = .50, P < .02). 
      Blood glucose remained unchanged, while insulin decreased in both diets. Free 
      fatty acids (FFA) significantly increased only after the HC diet (P < .05). 
      During the clamp period, glucose disposal and glucose oxidation significantly 
      increased after the HP diet and significantly decreased after the HC diet. 
      Opposite results were found when measuring lipid oxidation. In conclusion, our 
      experience suggests that (1) a hypocaloric diet providing a high percentage of 
      natural protein can improve insulin sensitivity; and (2) conversely, a 
      hypocaloric high-polysaccharide-CHO diet decreases insulin sensitivity and is 
      unable to spare muscle tissue.
FAU - Piatti, P M
AU  - Piatti PM
AD  - Istituto Scientifico San Raffaele, Dipartimento di Chimica e Biochimica Medica, 
      Milano, Italy.
FAU - Monti, F
AU  - Monti F
FAU - Fermo, I
AU  - Fermo I
FAU - Baruffaldi, L
AU  - Baruffaldi L
FAU - Nasser, R
AU  - Nasser R
FAU - Santambrogio, G
AU  - Santambrogio G
FAU - Librenti, M C
AU  - Librenti MC
FAU - Galli-Kienle, M
AU  - Galli-Kienle M
FAU - Pontiroli, A E
AU  - Pontiroli AE
FAU - Pozza, G
AU  - Pozza G
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Proteins)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Body Composition/*physiology
MH  - Body Mass Index
MH  - *Diet, Reducing
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Proteins/*administration & dosage
MH  - Energy Intake/physiology
MH  - Female
MH  - Glucose/*metabolism
MH  - Glucose Clamp Technique
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Lipid Peroxidation/physiology
MH  - Obesity/*diet therapy
MH  - Oxidation-Reduction
MH  - Proteins/metabolism
MH  - Weight Loss/physiology
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 0026-0495(94)90005-1 [pii]
AID - 10.1016/0026-0495(94)90005-1 [doi]
PST - ppublish
SO  - Metabolism. 1994 Dec;43(12):1481-7. doi: 10.1016/0026-0495(94)90005-1.