PMID- 7992258
OWN - NLM
STAT- MEDLINE
DCOM- 19950109
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 75
IP  - 5
DP  - 1994 Sep 1
TI  - Plasma TFPI activity after intravenous injection of pentasaccharide (PS) and 
      unfractionated heparin in rabbits.
PG  - 577-80
AB  - Tissue Factor Pathway Inhibitor (TFPI), is known, to be released in plasma after 
      injection of intravenous or subcutaneous injection of heparin or low molecular 
      weight heparin (1,2). Addition of protamine or polybrene in plasma can neutralize 
      anticoagulant effects of heparin in vitro but not completely ex vivo in patients 
      treated with heparin (3). It was believed for many years that this post-heparin 
      anticoagulant effect was due to another activity released by heparin. More 
      recently it has been shown that post-heparin anticoagulant effect could be 
      inhibited by anti-TFPI antibodies (4). Since we have shown in a previous work 
      (5), that in healthy volunteers, pharmacokinetics of TFPI were more closely 
      related to anti IIa activity than anti Xa activity we hypothesized that fragments 
      with anti-IIa activity may be required for this release, possibly from vascular 
      wall. In order to determine if a very low molecular weight glycosaminoglycan can 
      release TFPI in plasma, in the present study, we compared plasma TFPI amidolytic 
      activity after intravenous injection in rabbits of pentasaccharide (PS), a 
      synthetic fragment of very low molecular weight and with a strong and exclusive 
      anti Xa activity, and unfractionated heparin (UFH).
FAU - Zitoun, D
AU  - Zitoun D
AD  - Laboratoire thrombose Experimentale, Faculte de Medecine, Paris, France.
FAU - Bara, L
AU  - Bara L
FAU - Bloch, M F
AU  - Bloch MF
FAU - Samama, M M
AU  - Samama MM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Lipoproteins)
RN  - 0 (Oligosaccharides)
RN  - 0 (lipoprotein-associated coagulation inhibitor)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Fibrinolytic Agents/*blood/pharmacokinetics
MH  - Heparin/administration & dosage/*pharmacology
MH  - Heparin, Low-Molecular-Weight/administration & dosage/pharmacology
MH  - Injections, Intravenous
MH  - Lipoproteins/*blood/pharmacokinetics
MH  - Male
MH  - Oligosaccharides/administration & dosage/*pharmacology
MH  - Rabbits
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - 0049-3848(94)90232-1 [pii]
AID - 10.1016/0049-3848(94)90232-1 [doi]
PST - ppublish
SO  - Thromb Res. 1994 Sep 1;75(5):577-80. doi: 10.1016/0049-3848(94)90232-1.