PMID- 7996804
OWN - NLM
STAT- MEDLINE
DCOM- 19950118
LR  - 20220330
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 46
IP  - 3
DP  - 1994 Sep
TI  - Amino acid and albumin losses during hemodialysis.
PG  - 830-7
AB  - Protein and calorie malnutrition are prevalent in chronic hemodialysis (HD) 
      patients and has been linked to increased mortality and morbidity in this patient 
      population. Concern has been raised that the open pore structure of high flux 
      membranes may induce the loss of more amino acids (AA) compared to low flux 
      membranes. To address this issue, we prospectively analyzed pre- and post-HD 
      plasma AA profiles with three different membranes in nine patients. 
      Simultaneously, we measured dialysate AA losses during HD. The membranes studied 
      were: cellulosic (cuprophane-CU), low flux polymethylmethacrylate (LF-PMMA), and 
      high flux polysulfone (HF-PS) during their first use. Our results show that 
      pre-HD plasma AA profiles were abnormal compared to controls and decreased 
      significantly during HD with all dialyzers. The use of HF-PS membranes resulted 
      in significantly more AA losses into the dialysate when compared to LF-PMMA 
      membranes (mean +/- SD; 8.0 +/- 2.8 g/dialysis for HF-PS, 6.1 +/- 1.5 g/dialysis 
      for LF-PMMA, p < 0.05, and 7.2 +/- 2.6 g/dialysis for CU membranes, P = NS). When 
      adjusted for surface area and blood flow, AA losses were not different between 
      any of the dialyzers. We also measured dialysate AA losses during the sixth reuse 
      of the HF-PS membrane. Losses of total AA increased by 50% during the sixth reuse 
      of HF-PS membrane compared to its first use. In addition, albumin was detected in 
      the dialysate during the sixth reuse of HF-PS membrane. We therefore measured 
      albumin losses in all patients dialyzed with HF-PS membranes as a function of 
      reuse.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Ikizler, T A
AU  - Ikizler TA
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee.
FAU - Flakoll, P J
AU  - Flakoll PJ
FAU - Parker, R A
AU  - Parker RA
FAU - Hakim, R M
AU  - Hakim RM
LA  - eng
GR  - DK-20593/DK/NIDDK NIH HHS/United States
GR  - DK-26657/DK/NIDDK NIH HHS/United States
GR  - DK-45604-01/DK/NIDDK NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Amino Acids)
RN  - 0 (Dialysis Solutions)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Dialysis Solutions/metabolism
MH  - Humans
MH  - Male
MH  - Membranes, Artificial
MH  - Middle Aged
MH  - Prospective Studies
MH  - Protein-Energy Malnutrition/etiology
MH  - Renal Dialysis/*adverse effects
MH  - Serum Albumin/*metabolism
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - S0085-2538(15)58620-1 [pii]
AID - 10.1038/ki.1994.339 [doi]
PST - ppublish
SO  - Kidney Int. 1994 Sep;46(3):830-7. doi: 10.1038/ki.1994.339.