PMID- 7998696
OWN - NLM
STAT- MEDLINE
DCOM- 19950119
LR  - 20031114
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 55
IP  - 10
DP  - 1994 Oct
TI  - Temporal characterization of transplacental infection of porcine fetuses with 
      porcine reproductive and respiratory syndrome virus.
PG  - 1391-8
AB  - Pregnant gilts were exposed to porcine reproductive and respiratory syndrome 
      virus (PRRSV) by IV inoculation at or about gestation day 30 (3 gilts), 50 (3 
      gilts), 70 (3 gilts), or 90 (5 gilts) to investigate the likelihood of 
      transplacental infection with PRRSV at various stages of gestation. At or about 
      3, 6, and 9 weeks after exposure, gilts were either euthanatized while still 
      pregnant or allowed to farrow. Gilts and pigs were observed for clinical signs of 
      infection, and gilts, pigs, and fetuses were tested for PRRSV and homologous 
      antibody. All gilts were healthy throughout the study, except that farrowing was 
      sometimes difficult and prolonged, and 2 gilts failed to farrow the entire 
      litter. One gilt farrowed on day 111 of gestation; all others farrowed on day 114 
      or later. Porcine reproductive and respiratory virus was isolated from 
      significantly (chi 2 test, P < 0.01) more fetuses and live and stillborn pigs of 
      the 5 gilts that were infected at 90 or 92 days of gestation than from the 
      fetuses and live and stillborn pigs of the 9 gilts that were infected at 72 or 
      fewer days of gestation (ie, 33 of 44, 75% vs 3 of 78, 4%). After initial 
      infection, PRRSV was isolated from gilts and their pigs for a maximum of 3 weeks 
      and 8 to 11 weeks, respectively. Findings of this study, with regard to the 
      temporal aspects of transplacental infection, may help explain why natural 
      epizootics of PRRSV-induced maternal reproductive failure are often recognized 
      principally as problems of late-term gestation and neonatal survival.
FAU - Mengeling, W L
AU  - Mengeling WL
AD  - Virology Swine Research Unit, National Animal Disease Center, USDA, Ames, IA 
      50010.
FAU - Lager, K M
AU  - Lager KM
FAU - Vorwald, A C
AU  - Vorwald AC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Female
MH  - Fetal Diseases/*veterinary/virology
MH  - Gestational Age
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*veterinary/virology
MH  - Swine
MH  - Swine Diseases/*transmission/virology
MH  - Virus Diseases/transmission/*veterinary
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
PST - ppublish
SO  - Am J Vet Res. 1994 Oct;55(10):1391-8.