PMID- 7998698
OWN - NLM
STAT- MEDLINE
DCOM- 19950119
LR  - 20131121
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 55
IP  - 10
DP  - 1994 Oct
TI  - Effects of protein, lipid, or carbohydrate supplementation on hepatic lipid 
      accumulation during rapid weight loss in obese cats.
PG  - 1406-15
AB  - Effects of restricted tube-feeding (25% of energy requirements) of protein, 
      lipid, or carbohydrates on body weight loss; hematologic and clinical chemical 
      variables; plasma lipid and amino acid concentrations; nitrogen balance; and 
      hepatic histologic features and lipid concentrations were compared with values in 
      voluntary-fasting cats (control, CON). Twelve obese cats (6.1 +/- 0.1 kg, > 40% 
      above optimal body weight) were randomly assigned to 4 matched treatment groups 
      (n = 3)--protein (PRO), lipid (LIP), carbohydrate (CHO), and CON--and were 
      offered a low-palatability diet for 4 weeks. Cats of the PRO, LIP, and CHO groups 
      were also tube-fed isocaloric amounts (88 kcal of metabolizable energy) of a 
      casein-soybean protein mixture, corn oil, or a dextrin-dextrose mixture, 
      respectively, during the 4 weeks. All cats fasted, rather than eat the 
      low-palatability purified diet. Cats of the PRO group lost weight at a lower rate 
      (P < 0.05) than did cats of other groups. After 4 weeks of fasting, serum 
      alkaline phosphatase activities were higher than reference values in all cats of 
      the CON and LIP groups and in 2 cats of the CHO group. At that time, 1 cat of the 
      LIP group had lethargy, hepatomegaly, and hyperbilirubinemia. Total hepatic lipid 
      and triglyceride concentrations increased in all groups during the study, but the 
      increase was significantly (P < 0.05) less in cats of the PRO group, compared 
      with those of the CON and LIP groups, and those of the CHO group, compared with 
      those of the LIP group.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Biourge, V C
AU  - Biourge VC
AD  - Department of Molecular Biosciences, School of Veterinary Medicine, University of 
      California, Davis 95616.
FAU - Massat, B
AU  - Massat B
FAU - Groff, J M
AU  - Groff JM
FAU - Morris, J G
AU  - Morris JG
FAU - Rogers, Q R
AU  - Rogers QR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Cell Count/veterinary
MH  - Body Weight
MH  - Cat Diseases/*diet therapy/*metabolism
MH  - Cats
MH  - Diet, Reducing/*veterinary
MH  - Dietary Carbohydrates/pharmacology
MH  - Dietary Fats/pharmacology
MH  - Dietary Proteins/pharmacology
MH  - Female
MH  - *Lipid Metabolism
MH  - Liver/*metabolism
MH  - Male
MH  - Nitrogen/metabolism
MH  - Obesity/diet therapy/metabolism/*veterinary
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
PST - ppublish
SO  - Am J Vet Res. 1994 Oct;55(10):1406-15.