PMID- 7998789
OWN - NLM
STAT- MEDLINE
DCOM- 19950113
LR  - 20191023
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 36 Suppl 2
DP  - 1994 Dec
TI  - Genetic susceptibility to multiple sclerosis.
PG  - S204-10
AB  - Twin studies have established that susceptibility to multiple sclerosis (MS) is 
      partly genetic. Attempts to identify the relevant genetic loci have involved 
      population-based studies, to detect associations between a genetic marker and MS, 
      and family studies, to detect linkage between a putative marker and MS. Most of 
      this genetic work is driven by the view that MS is an autoimmune disease. Thus, 
      the focus has been mainly on genes known to be important in the immune response: 
      human leukocyte antigen (HLA) genes, T-cell receptor genes, and immunoglobulin 
      genes. To date, only the particular HLA-DR2 haplotype that is common in 
      Caucasians can be concluded to be important in MS susceptibility in most 
      populations. Studies of other genetic loci have been few, the data obtained often 
      have been conflicting or controversial, and further studies are needed to clarify 
      the biological significance of these loci in MS. Recommendations for further 
      studies are provided in order to overcome some of the problems that have plagued 
      earlier work in MS such as nonreproducibility of results.
FAU - Haegert, D G
AU  - Haegert DG
AD  - Discipline of Pathology, Memorial University of Newfoundland, St. John's, Canada.
FAU - Marrosu, M G
AU  - Marrosu MG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - Polymorphism, Genetic
MH  - Receptors, Antigen, T-Cell/genetics
MH  - Twin Studies as Topic
RF  - 71
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
AID - 10.1002/ana.410360807 [doi]
PST - ppublish
SO  - Ann Neurol. 1994 Dec;36 Suppl 2:S204-10. doi: 10.1002/ana.410360807.