PMID- 7999061
OWN - NLM
STAT- MEDLINE
DCOM- 19950117
LR  - 20191210
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 205
IP  - 1
DP  - 1994 Nov 30
TI  - Cell-type-specific induction of the UL9 gene of HSV-1 by cell signaling pathway.
PG  - 44-51
AB  - The origin-binding protein, encoded by the UL9 gene of herpes simplex virus-1 
      (HSV-1), has the properties of an initiator of DNA replication. In this 
      communication, we report that the UL9 promoter contains a cAMP-response element 
      (CRE). Transient expression analyses show that dibutyryl cyclic AMP, known to 
      elevate intracellular cAMP level, can induce the UL9 promoter in a rat 
      pheochromocytoma cell line (PC12) but not in a non-neuronal human cell line 
      (HeLa). Interestingly, a transcription factor that increases expression of a 
      neuropeptide gene by interacting with CRE can also activate the UL9 promoter 
      independent of cell type. Thus, our data suggest that extracellular stimuli, 
      capable of interacting with the signaling pathway in neuronal cells, can activate 
      UL9 gene expression, and different proteins may regulate UL9 expression in 
      different cell types.
FAU - Deb, S P
AU  - Deb SP
AD  - Department of Microbiology, University of Texas Health Science Center at San 
      Antonio, 78284-7758.
FAU - Deb, S
AU  - Deb S
FAU - Brown, D R
AU  - Brown DR
LA  - eng
GR  - AI31498-02/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (CCAAT-Enhancer-Binding Proteins)
RN  - 0 (DNA, Recombinant)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Viral Proteins)
RN  - 115004-77-8 (UL9 protein, Human herpesvirus 1)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
RN  - EC 3.6.4.- (DNA Helicases)
SB  - IM
GS  - UL9
MH  - Animals
MH  - Base Sequence
MH  - Bucladesine/pharmacology
MH  - CCAAT-Enhancer-Binding Proteins
MH  - Chlorocebus aethiops
MH  - Cyclic AMP-Dependent Protein Kinases/metabolism
MH  - DNA Helicases/*genetics/metabolism
MH  - DNA, Recombinant
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Enzyme Activation
MH  - Gene Expression Regulation, Viral/drug effects
MH  - HeLa Cells
MH  - Herpesvirus 1, Human/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/metabolism
MH  - PC12 Cells
MH  - Promoter Regions, Genetic
MH  - Rats
MH  - *Signal Transduction
MH  - Vero Cells
MH  - Viral Proteins/*genetics/metabolism
EDAT- 1994/11/30 00:00
MHDA- 1994/11/30 00:01
CRDT- 1994/11/30 00:00
PHST- 1994/11/30 00:00 [pubmed]
PHST- 1994/11/30 00:01 [medline]
PHST- 1994/11/30 00:00 [entrez]
AID - S0006-291X(84)72627-1 [pii]
AID - 10.1006/bbrc.1994.2627 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1994 Nov 30;205(1):44-51. doi: 
      10.1006/bbrc.1994.2627.