PMID- 7999313
OWN - NLM
STAT- MEDLINE
DCOM- 19950125
LR  - 20200304
IS  - 0893-7648 (Print)
IS  - 0893-7648 (Linking)
VI  - 8
IP  - 2-3
DP  - 1994 Apr-Jun
TI  - Genetic and phylogenetic analyses of human T-cell lymphotropic virus type I 
      variants from Melanesians with and without spastic myelopathy.
PG  - 155-73
AB  - Molecular variants of human T-cell lymphotropic virus type I (HTLV-I) have been 
      isolated recently from lifelong residents of remote Melanesian populations, 
      including a Solomon Islander with tropical spastic paraparesis/HTLV-I-associated 
      myelopathy (TSP/HAM) or HTLV-I myeloneuropathy. To clarify the genetic 
      heterogeneity and molecular epidemiology of disease-associated strains of HTLV-I, 
      we enzymatically amplified, then directly sequenced representative regions of the 
      gag, pol, env, and pX genes of HTLV-I strains from Melanesians with and without 
      TSP/HAM, and aligned and compared these sequences with those of HTLV-I strains 
      from patients with TSP/HAM or adult T-cell leukemia/lymphoma and from 
      asymptomatic carriers from widely separated and culturally disparate populations. 
      Overall, the HTLV-I variant from the Solomon Islander with TSP/HAM, like HTLV-I 
      strains from asymptomatically infected Melanesians, diverged by approx 7% from 
      cosmopolitan HTLV-I strain. No disease-specific viral sequences were found. Gene 
      phylogenies, as determined by the unweighted pair-group method of assortment and 
      by the maximum parsimony method, indicated that the Melanesian and cosmopolitan 
      strains of HTLV-I have evolved along separate geographically dependent lineages, 
      one comprised of HTLV-I strains from Papua New Guinea and the Solomon Islands, 
      and the other composed of virus strains from Japan, India, the Caribbean, 
      Polynesia, the Americas, and Africa. The total absence of nonhuman primates in 
      Papua New Guinea and the Solomon Islands precludes any possibility that the 
      Melanesian HTLV-I strains have evolved recently from the simian homolog of 
      HTLV-I.
FAU - Nerurkar, V R
AU  - Nerurkar VR
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
FAU - Song, K J
AU  - Song KJ
FAU - Melland, R R
AU  - Melland RR
FAU - Yanagihara, R
AU  - Yanagihara R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (DNA Primers)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
GS  - env
GS  - gag
GS  - pX
GS  - pol
MH  - Adult
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Line
MH  - DNA Primers
MH  - Genes, env
MH  - Genes, gag
MH  - Genes, pX
MH  - Genes, pol
MH  - Genetic Variation
MH  - Human T-lymphotropic virus 1/classification/*genetics/isolation & purification
MH  - Humans
MH  - Melanesia
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Papua New Guinea
MH  - Paraparesis, Tropical Spastic/*virology
MH  - *Phylogeny
MH  - Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - T-Lymphocytes
MH  - Viral Envelope Proteins/chemistry/genetics
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1007/BF02780667 [doi]
PST - ppublish
SO  - Mol Neurobiol. 1994 Apr-Jun;8(2-3):155-73. doi: 10.1007/BF02780667.