PMID- 8002337
OWN - NLM
STAT- MEDLINE
DCOM- 19950120
LR  - 20190920
IS  - 0017-8470 (Print)
IS  - 0017-8470 (Linking)
VI  - 45
IP  - 10
DP  - 1994 Oct
TI  - [Course and prognosis of subacute cutaneous lupus erythematosus. A prospective 
      study of 34 patients].
PG  - 690-5
AB  - 34 patients with subacute cutaneous lupus erythematosus (SCLE) were prospectively 
      followed up and examined twice in 1986-1989 and 1990-1991, with a minimal 
      interval of 2 years. The findings obtained were documented in a computerized 
      registry and were evaluated by computer-assisted analysis. Thirty-one women and 
      three men aged 23-66 years at the time of the first documentation (FD) were 
      included in the study. The disease had lasted an average 6.5 years (from a few 
      months to 39 years). Prominent cutaneous manifestations of SCLE were shown by 
      79.4% of the patients at the first visit compared to 58.8% at the second 
      documentation (SD), whereas the incidence of acrolocalized vasculitis increased 
      (FD 20.6%, SD 41.2%), as did that of Raynaud phenomenon (FD 20.6%, SD 26.5%). 
      Mild extracutaneous symptomatology was found in 70.6% (FD) and in 85.3% (SD) of 
      the SCLE patients. Arthralgia (FD 47%, SD 61.8%) and symptoms suggesting some 
      involvement of the peripheral or central nervous system (FD 29.4%, SD 50%) were 
      noted most frequently. Overall, during the follow-up there was a quantitative 
      mild increase of extracutaneous symptomatology; a significant correlation between 
      the presence of acrolocalized vasculitis and arthralgia was found. In conclusion, 
      the prognosis of SCLE appears rather benign; fulminant courses were not observed. 
      However, the risk of mild systemic involvement clearly increases during the 
      prospective course of the disease, whereby acrolocalized vasculitis can be 
      regarded as a cutaneous marker for extracutaneous manifestations.
FAU - Tebbe, B
AU  - Tebbe B
AD  - Universitats-Hautklinik und Poliklinik, Klinikum Benjamin Franklin, Freie 
      Universitat Berlin.
FAU - Hoffmann, S
AU  - Hoffmann S
FAU - Orfanos, C E
AU  - Orfanos CE
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Verlauf und Prognose des subakut-kutanen Lupus erythematodes. Eine prospektive 
      Studie an 34 Patienten.
PL  - Germany
TA  - Hautarzt
JT  - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
JID - 0372755
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Acrodermatitis/diagnosis
MH  - Adult
MH  - Aged
MH  - Antibodies, Antinuclear/analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*diagnosis
MH  - Lupus Erythematosus, Systemic/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Raynaud Disease/diagnosis
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
AID - 10.1007/s001050050151 [doi]
PST - ppublish
SO  - Hautarzt. 1994 Oct;45(10):690-5. doi: 10.1007/s001050050151.