PMID- 8005976
OWN - NLM
STAT- MEDLINE
DCOM- 19940720
LR  - 20041117
IS  - 0004-5772 (Print)
IS  - 0004-5772 (Linking)
VI  - 41
IP  - 6
DP  - 1993 Jun
TI  - Anti-lymphocyte globulin therapy in acquired aplastic anaemia.
PG  - 371-3
AB  - Thirty five patients with acquired aplastic anaemia (AAA) were treated with 
      anti-lymphocyte globulin (ALG). Fifteen (42.9%) had non-severe aplastic anaemia 
      (NSAA), 14 (40%) severe aplastic anaemia (SAA) and 6 very severe aplastic anaemia 
      (VSAA). There were 17 (48.6%) responders to the first course of ALG while 2 out 
      of 5 (40%) responded to a second course, the overall response rate being 54.3%. 
      Eleven out of 15 (73.3%) with NSAA responded, 8 out of 20 (40%) with SAA 
      responded while none of VSAA responded. All the non-responders have died. Out of 
      the responders, 1 died of non-A non-B hepatitis, and 1 with relapse of AA and 
      sepsis. One has developed paroxysmal nocturnal haemoglobinuria (PNH) and one 
      myelodysplasia. Another 2 needed infrequent red cell transfusion support. 
      Remaining 13 (37.1%) are asymptomatic and without any external support since 
      18-78 months (35 +/- 21). We conclude that ALG is an effective modality of 
      treatment for patients with AAA.
FAU - Agarwal, M B
AU  - Agarwal MB
AD  - Bombay Hospital P.G. Institute of Medical Sciences, Marine Lines.
FAU - Agarwal, U M
AU  - Agarwal UM
FAU - Bhave, A B
AU  - Bhave AB
FAU - Vishwanathan, C
AU  - Vishwanathan C
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Assoc Physicians India
JT  - The Journal of the Association of Physicians of India
JID - 7505585
RN  - 0 (Antilymphocyte Serum)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Aplastic/etiology/mortality/*therapy
MH  - Antilymphocyte Serum/*administration & dosage/adverse effects
MH  - Child
MH  - *Developing Countries
MH  - Female
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Survival Rate
EDAT- 1993/06/01 00:00
MHDA- 1993/06/01 00:01
CRDT- 1993/06/01 00:00
PHST- 1993/06/01 00:00 [pubmed]
PHST- 1993/06/01 00:01 [medline]
PHST- 1993/06/01 00:00 [entrez]
PST - ppublish
SO  - J Assoc Physicians India. 1993 Jun;41(6):371-3.