PMID- 8006296
OWN - NLM
STAT- MEDLINE
DCOM- 19940715
LR  - 20190909
IS  - 0731-5724 (Print)
IS  - 0731-5724 (Linking)
VI  - 13
IP  - 2
DP  - 1994 Apr
TI  - Glycolysis abnormalities in fibromyalgia.
PG  - 144-8
AB  - OBJECTIVE: Primary fibromyalgia (FM) is a painful condition, generally treated by 
      analgesic drugs and antidepressants, which has been associated with 
      hyperpyruvicemia and reduced high energy phosphate in muscle. Biological 
      investigations were performed in patients with FM to determine whether this 
      syndrome was related to carbohydrate metabolism impairment. METHOD: Glycolysis 
      was studied in 25 patients with FM, 10 patients with hypothyroidism (HO), 15 
      patients with osteoarticular chronic pain (OACP), and 36 healthy controls. 
      Laboratory studies were performed on whole blood (pyruvate), erythrocytes 
      (pyruvate kinase, 2-3 diphosphoglycerate, glyceraldehyde phosphodeshydrogenase, 
      adenosine triphosphate), plasma and serum (lactate at rest and after forearm 
      ischemic exercise, lactico deshydrogenase iso-enzymes). RESULTS: Comparisons 
      between study groups and controls demonstrated increased pyruvate and decreased 
      lactate production in FM and HO; adenosine triphosphate and muscular isoenzymes 
      of lacticodeshydrogenase were decreased in FM only; glycolysis was not 
      significantly impaired in OACP. CONCLUSIONS: These findings provide support that 
      FM is associated with biochemical abnormalities which require appropriate 
      metabolic therapy.
FAU - Eisinger, J
AU  - Eisinger J
AD  - Department of Rheumatic Diseases--Centre Hospitalier, Toulon, France.
FAU - Plantamura, A
AU  - Plantamura A
FAU - Ayavou, T
AU  - Ayavou T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Diphosphoglyceric Acids)
RN  - 0 (Lactates)
RN  - 0 (Pyruvates)
RN  - 138-81-8 (2,3-Diphosphoglycerate)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 8558G7RUTR (Pyruvic Acid)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - 9002-72-6 (Growth Hormone)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - 2,3-Diphosphoglycerate
MH  - Adenosine Triphosphate/blood
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/blood
MH  - Diphosphoglyceric Acids/blood
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Fibromyalgia/*blood
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/*blood
MH  - *Glycolysis
MH  - Growth Hormone/blood
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Lactates/blood
MH  - Lactic Acid
MH  - Leukocytes/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pyruvate Kinase/blood
MH  - Pyruvates/blood
MH  - Pyruvic Acid
MH  - Reference Values
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1080/07315724.1994.10718387 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 1994 Apr;13(2):144-8. doi: 10.1080/07315724.1994.10718387.