PMID- 8006429
OWN - NLM
STAT- MEDLINE
DCOM- 19940719
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 102
IP  - 6
DP  - 1994 Jun
TI  - Epidemiology and the genetics of psoriasis.
PG  - 24S-27S
AB  - Several lines of compelling epidemiologic evidence indicate that susceptibility 
      to psorasis is inherited, albeit not in a simple monogenic fashion. Psoriasis is 
      one of a number of diseases with a presumed autoimmune pathogenesis that display 
      significant human leukocyte antigen (HLA) associations. However, only a small 
      fraction of those who carry the implicated HLA susceptibility alleles develop 
      disease. Taken together with the epidemiologic data indicative of high 
      heritability, this observations suggests that one or more loci in addition to HLA 
      are necessary for the development of psoriasis. As the identity of these other 
      genes is unknown, genetic linkage analysis offers an attractive strategy for 
      their identification. To this end, we have initiated a large linkage study of 
      multiplex psoriasis kindreds, and PCR-based genotyping of CA repeat polymorphisms 
      has been performed for several markers in the HLA region (6p21.3). As expected 
      given the hypothesis of oligogenic inheritance, these analyses have thus far 
      failed to reveal tight linkage of psoriasis to the 6p21 region. Nevertheless, the 
      substantial homogeneity of the psoriatric phenotype and the clear evidence for 
      increased HLA association and heritability in juvenile onset disease (40 years) 
      indicate that, like insulin-dependent diabetes mellitus, psoriasis is an 
      HLA-associated, genetically complex disease whose etiology is potentially 
      amenable to elucidation through linkage analysis.
FAU - Elder, J T
AU  - Elder JT
AD  - Department of Dermatology, University of Michigan, Ann Arbor 48109-0672.
FAU - Nair, R P
AU  - Nair RP
FAU - Voorhees, J J
AU  - Voorhees JJ
LA  - eng
GR  - M01RR00042/RR/NCRR NIH HHS/United States
GR  - NCHGR P30 HG00209-03/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Pedigree
MH  - Psoriasis/*epidemiology/*genetics/immunology
RF  - 54
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1111/1523-1747.ep12386091 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1994 Jun;102(6):24S-27S. doi: 10.1111/1523-1747.ep12386091.