PMID- 8006599
OWN - NLM
STAT- MEDLINE
DCOM- 19940721
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 180
IP  - 1
DP  - 1994 Jul 1
TI  - Anti-immunoglobulin E treatment decreases worm burden and egg production in 
      Schistosoma mansoni-infected normal and interferon gamma knockout mice.
PG  - 43-51
AB  - The immunoglobulin E (IgE) response is generally considered an essential 
      component of the host defense against parasitic helminths such as Schistosoma 
      mansoni. In contrast, work on antischistosome vaccines suggests that interferon 
      gamma (IFN-gamma) is the critical immune mediator for vaccine-induced immunity to 
      the parasite. In this study, the total IgE response to a primary S. mansoni 
      infection was suppressed by anti-IgE treatment in both normal mice and in mice 
      with defective IFN genes (gene knockout [GKO]). Reduction of the IgE response 
      resulted in decreased worm burden and a decrease in the number of eggs produced 
      per worm in both normal and GKO mice. Whereas anti-IgE treatment also resulted in 
      reduced hepatosplenomegaly, granulomas around existing schistosome eggs showed 
      normal cellularity. Serum interleukin 4 levels fell in response to the reduction 
      in serum IgE as well. The data suggest that IgE plays a detrimental, rather than 
      beneficial, role for the host in schistosomiasis. Furthermore, the absence of 
      IFN-gamma was found to be of little consequence to the host-response to adults or 
      eggs in a primary schistosome infection.
FAU - Amiri, P
AU  - Amiri P
AD  - Department of Immunology, Genentech, Inc., South San Francisco, California 
      94080-4990.
FAU - Haak-Frendscho, M
AU  - Haak-Frendscho M
FAU - Robbins, K
AU  - Robbins K
FAU - McKerrow, J H
AU  - McKerrow JH
FAU - Stewart, T
AU  - Stewart T
FAU - Jardieu, P
AU  - Jardieu P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (anti-IgE antibodies)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/immunology
MH  - Immunoglobulin E/*physiology
MH  - Interferon-gamma/genetics/*physiology
MH  - Interleukin-4/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Ovum/immunology/physiology
MH  - Schistosoma mansoni/isolation & purification
MH  - Schistosomiasis mansoni/*immunology/parasitology
PMC - PMC2191578
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
PMCR- 1995/01/01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
PHST- 1995/01/01 00:00 [pmc-release]
AID - 94275400 [pii]
AID - 10.1084/jem.180.1.43 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Jul 1;180(1):43-51. doi: 10.1084/jem.180.1.43.