PMID- 8007773
OWN - NLM
STAT- MEDLINE
DCOM- 19940721
LR  - 20190904
IS  - 0730-725X (Print)
IS  - 0730-725X (Linking)
VI  - 12
IP  - 3
DP  - 1994
TI  - Biodistribution of an ultrasmall superparamagnetic iron oxide colloid, BMS 
      180549, by different routes of administration.
PG  - 433-42
AB  - The ultrasmall superparamagnetic iron oxide colloid BMS 180549 can be found lymph 
      nodes by either subcutaneous (SC) or intravenous (IV) injection. With an SC 
      injection in the front extremities, the axillary and brachial nodes attain the 
      highest accumulations of the agent. With an SC injection in the rear extremities, 
      the popliteal, iliac, and axillary nodes attain highest accumulations of the 
      agent. With IV injection of the agent, the iliac, mediastinal and mesenteric 
      nodes attain highest accumulations of the agent. Though the spleen is not 
      involved with the drainage of the interstitial space near the site of SC 
      injections, the mobility of BMS 180549 from such injection sites increases 
      splenic relaxation rates. Based on a knowledge of the lymphatic system, a route 
      of administration of BMS 180549 can be chosen to maximize the delivery of the 
      agent to specific lymph nodes.
FAU - Bengele, H H
AU  - Bengele HH
AD  - Advanced Magnetics Inc., Cambridge, MA 02138.
FAU - Palmacci, S
AU  - Palmacci S
FAU - Rogers, J
AU  - Rogers J
FAU - Jung, C W
AU  - Jung CW
FAU - Crenshaw, J
AU  - Crenshaw J
FAU - Josephson, L
AU  - Josephson L
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Oxides)
RN  - 0 (ferumoxtran-10)
RN  - E1UOL152H7 (Iron)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Animals
MH  - Contrast Media/administration & dosage/*pharmacokinetics
MH  - Dextrans
MH  - Ferrosoferric Oxide
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Iron/administration & dosage/*pharmacokinetics
MH  - Lymph Nodes/anatomy & histology/*metabolism
MH  - Magnetic Resonance Imaging
MH  - Magnetite Nanoparticles
MH  - Oxides/administration & dosage/*pharmacokinetics
MH  - Rats
MH  - Tissue Distribution
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 0730-725X(94)92537-2 [pii]
AID - 10.1016/0730-725x(94)92537-2 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 1994;12(3):433-42. doi: 10.1016/0730-725x(94)92537-2.