PMID- 8010591
OWN - NLM
STAT- MEDLINE
DCOM- 19940721
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 719
DP  - 1994 May 31
TI  - Mechanisms of caloric restriction affecting aging and disease.
PG  - 159-70
AB  - Caloric restriction (CR) appears to affect aging by the inhibition of the 
      specific chronic diseases which occur at increasing frequency with age. A common 
      disease in F-344 rats, granulocytic leukemia, appears to have a window where it 
      is sensitive to the effects of CR. Other diseases, such as pituitary adenomas, 
      appear to have a different relationship to growth in the animal. Additionally, a 
      model for the major disease for a number of long-lived strains of mice, lymphoma, 
      which CR effects by inhibiting the expression of the causative agent, is being 
      developed. Evaluation of the effects of CR on neoplasia, degenerative disease and 
      physiological parameters suggests that the major factors in expression of these 
      diseases is the alteration of growth factors, hormonal status, etc., and that 
      these alterations also affect strain-specific pathologies depending on when they 
      are changed in the life span. Effecting different diseases at different times in 
      the life span, long-term CR, by limiting exposure to endogenous growth factors, 
      altering physiological characteristics, and limiting exposure to food toxicants, 
      inhibits the onset of disease, and its sequela, aging.
FAU - Turturro, A
AU  - Turturro A
AD  - Division of Biometry and Risk Assessment, National Center for Toxicological 
      Research, Jefferson, Arizona 72079.
FAU - Blank, K
AU  - Blank K
FAU - Murasko, D
AU  - Murasko D
FAU - Hart, R
AU  - Hart R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Body Weight
MH  - *Energy Intake
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasms, Experimental/*physiopathology
MH  - Rats
MH  - Rats, Inbred F344
RF  - 24
EDAT- 1994/05/31 00:00
MHDA- 1994/05/31 00:01
CRDT- 1994/05/31 00:00
PHST- 1994/05/31 00:00 [pubmed]
PHST- 1994/05/31 00:01 [medline]
PHST- 1994/05/31 00:00 [entrez]
AID - 10.1111/j.1749-6632.1994.tb56827.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1994 May 31;719:159-70. doi: 
      10.1111/j.1749-6632.1994.tb56827.x.