PMID- 8011486
OWN - NLM
STAT- MEDLINE
DCOM- 19940722
LR  - 20061115
IS  - 1017-5644 (Print)
IS  - 1017-5644 (Linking)
VI  - 31
IP  - 3-4
DP  - 1993 Jul-Dec
TI  - Interictal responsiveness in therapy-resistant partial epilepsy.
PG  - 239-60
AB  - A polygraphic study of the somatic, autonomic and EEG components of the orienting 
      reaction elicited by an auditory stimulus was performed in 66 epileptics with 
      therapy-resistant partial seizures (TRPS) and in 135 matched subjects in two 
      control groups. The study showed a significant interictal hyperresponsivity in 
      epileptics with TRPS vs. the normal subjects of control group I, which consisted 
      in a marked increase of the intensity of the orienting reaction components. This 
      hyperresponsivity was also more marked than that noted in epileptics with 
      therapy-controlled partial seizures of control group II. The correlational 
      analysis of data showed that the severity of these responsiveness disturbances in 
      epileptics with TRPS depended on the patients' age, type of electroclinical 
      seizures, pretrial seizure frequency, type of resting EEG, administered treatment 
      (no. of administered antiepileptic drugs/patient), daily dose, as well as on the 
      serum level of these drugs. The multivariate regression analysis showed that the 
      most significant predictive variables for the responsiveness disturbances were 
      the pretrial seizure frequency, type of electroclinical seizures, daily dose of 
      administered antiepileptic drugs and their serum level. The data also evidenced 
      that the antiepileptic treatment improves the interictal responsiveness 
      disturbances, the effect being the more marked as the treatment was more 
      sustained. The above-mentioned responsiveness changes in epileptics with TRPS 
      should be ascribed to some disturbances in nervous excitability.
FAU - Rogozea, R
AU  - Rogozea R
AD  - Institute of Neurology and Psychiatry, Bucharest, Romania.
FAU - Florea-Ciocoiu, V
AU  - Florea-Ciocoiu V
FAU - Hategan, D
AU  - Hategan D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Romania
TA  - Rom J Neurol Psychiatry
JT  - Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et 
      psychiatrie
JID - 9014562
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Acoustic Stimulation
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/administration & dosage/*antagonists & inhibitors
MH  - Child
MH  - Dose-Response Relationship, Drug
MH  - Drug Resistance
MH  - Electroencephalography/drug effects/statistics & numerical data
MH  - Electromyography/drug effects/statistics & numerical data
MH  - Epilepsies, Partial/drug therapy/epidemiology/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Orientation/drug effects
MH  - Regression Analysis
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
PST - ppublish
SO  - Rom J Neurol Psychiatry. 1993 Jul-Dec;31(3-4):239-60.