PMID- 8011613
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20231213
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 71
IP  - 4
DP  - 1994 Apr
TI  - The effect of delayed weaning on the development of oral tolerance to soya-bean 
      protein in pigs.
PG  - 615-25
AB  - The antibody response to a dietary antigen (soya-bean protein) and the 
      development of oral tolerance was studied in pigs in a family pen system where 
      the piglets are left with their mothers and gradually wean themselves onto a 
      soya-bean-based diet over a 12 week period. In the first experiment three groups 
      of pigs (eight pigs/group) aged either 2, 8 or 13 weeks were immunized with 
      soya-bean protein or ovalbumin (OvA; controls) intra-peritoneally (i.p.) in Quill 
      A adjuvant and subsequently boosted 2 weeks later. All groups showed an IgG 
      response to the injected antigens indicating lack of tolerance induction to the 
      dietary antigen. Interestingly the groups injected with OvA showed an almost 
      identical response to soya-bean protein as the groups injected with soya-bean 
      protein. In a second experiment with a similar protocol, soya bean was withdrawn 
      from the feed before immunization which resulted in lack of response to soya-bean 
      protein in the groups injected with OvA and a lack of response to injected 
      soya-bean protein in the 14-week-old group, indicating that systemic tolerance 
      was established by 12 weeks of age. The results from the two experiments suggest 
      a compartmentalized response to soya-bean protein i.e. local antibody production 
      to dietary soya bean along with systemic tolerance to injected soya-bean protein. 
      The work also suggests that delayed 'natural' weaning may avoid damaging 
      hypersensitivity reactions associated with early weaning.
FAU - Miller, B G
AU  - Miller BG
AD  - School of Veterinary Science, Bristol University, Langford.
FAU - Whittemore, C T
AU  - Whittemore CT
FAU - Stokes, C R
AU  - Stokes CR
FAU - Telemo, E
AU  - Telemo E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Antibodies)
RN  - 0 (Dietary Proteins)
RN  - 0 (Plant Proteins, Dietary)
RN  - 0 (Soybean Proteins)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Aging/*immunology
MH  - Animals
MH  - Antibodies/blood
MH  - Dietary Proteins/*immunology
MH  - Immune Tolerance/*physiology
MH  - Immunization
MH  - Ovalbumin/administration & dosage
MH  - Plant Proteins, Dietary/*immunology
MH  - Soybean Proteins
MH  - *Glycine max
MH  - Swine/*immunology
MH  - *Weaning
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - S0007114594000668 [pii]
AID - 10.1079/bjn19940167 [doi]
PST - ppublish
SO  - Br J Nutr. 1994 Apr;71(4):615-25. doi: 10.1079/bjn19940167.