PMID- 8011777
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20220321
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 6
IP  - 1
DP  - 1994 Jan
TI  - Experimental porcine reproductive and respiratory syndrome virus infection in 
      one-, four-, and 10-week-old pigs.
PG  - 3-12
AB  - One-, 4-, and 10-week-old pigs were exposed to porcine reproductive and 
      respiratory syndrome virus (PRRSV) to determine the effect of age on clinical 
      signs, hematologic alterations, the onset and duration of viremia, routes of 
      virus shedding, antibody production, and microscopic lesions produced by PRRSV 
      isolate ATCC VR-2332. The response to PRRSV infection was similar among age 
      groups. Fever, usually prolonged, and a marked dyspnea with cutaneous erythema 
      when restrained for sample collection were the most consistent clinical signs. 
      Prolonged periocular edema was unique to the 1-week-old pigs. The white blood 
      cell count was decreased on day 4 postexposure (PE) due to decreases in 
      neutrophils and lymphocytes. The virus was isolated from buffy coats at day 1 PE 
      and was isolated from serum, buffy coat, or plasma at each sample collection 
      period through the end of the trial (day 28 PE). Virus was most consistently 
      isolated from lung, lymph node, spleen, and tonsil on day 7 PE and exclusively 
      from lymph node, spleen, and tonsil on day 28 PE. Virus was infrequently isolated 
      from urine and fecal and nasal swabs. Consistent microscopic changes in all age 
      groups included interstitial pneumonia and lymph node hypertrophy and hyperplasia 
      on days 7 and 28 PE, lymph node necrosis on day 7 PE, and subacute mononuclear 
      myocarditis on day 28 PE. Findings presented here indicate that interstitial 
      pneumonia, lymphoid necrosis, and mononuclear myocarditis are characteristic 
      lesions of PRRSV isolate ATCC VR-2332 infection in 1-, 4-, and 10-week-old pigs.
FAU - Rossow, K D
AU  - Rossow KD
AD  - Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, 
      University of Minnesota, St. Paul 55108.
FAU - Bautista, E M
AU  - Bautista EM
FAU - Goyal, S M
AU  - Goyal SM
FAU - Molitor, T W
AU  - Molitor TW
FAU - Murtaugh, M P
AU  - Murtaugh MP
FAU - Morrison, R B
AU  - Morrison RB
FAU - Benfield, D A
AU  - Benfield DA
FAU - Collins, J E
AU  - Collins JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Body Temperature
MH  - Female
MH  - Genital Diseases, Female/microbiology/physiopathology/*veterinary
MH  - Lung/growth & development/*pathology
MH  - *RNA Viruses
MH  - Respiratory Tract Diseases/microbiology/physiopathology/*veterinary
MH  - Swine
MH  - *Swine Diseases
MH  - Syndrome
MH  - Time Factors
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1177/104063879400600102 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 1994 Jan;6(1):3-12. doi: 10.1177/104063879400600102.