PMID- 8012736
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20131121
IS  - 1056-2044 (Print)
IS  - 1056-2044 (Linking)
VI  - 2
IP  - 6
DP  - 1993 Dec
TI  - Molecular biology of human herpesviruses 6A and 6B.
PG  - 343-60
AB  - Human herpesvirus 6 variant A (HHV-6A) and human herpesvirus 6 variant B (HHV-6B) 
      are closely related herpesviruses. No disease has been specifically associated 
      with HHV-6A, whereas HHV-6B is the major etiologic agent of exanthem subitum. 
      Both viruses may be opportunistic pathogens in the immunocompromised patient. 
      HHV-6 genomes have low G+C contents for herpesviruses (43%); they consist of a 
      141-kb unique segment that is flanked by single copies of a directly repeated 
      sequence that can vary from 10 to 13 kb. HHV-6A and HHV-6B encode homologs of 
      many conserved herpesvirus proteins and are classified as beta-herpesviruses 
      based on their close genetic relationship with human cytomegalovirus. HHV-6A and 
      HHV-6B are even more closely related to the recently discovered human herpesvirus 
      7. HHV-6 encodes homologs of the seven genes that are essential for 
      origin-dependent herpes simplex virus type 1 DNA replication, including the 
      origin-binding protein, which has no clear homolog in human cytomegalovirus. The 
      HHV-6B origin-binding protein binds to sequences with similarities to 
      alpha-herpesvirus replication origins that lie within a genomic segment that can 
      serve as a replication origin in transient replication assays. Both HHV-6 
      variants encode homologs of the adeno-associated virus type 2 Rep protein; the 
      role of this protein during infection is unknown. HHV-6 induces synthesis of a 
      broad range of host cell proteins, including interferon alpha, CD4, interleukin-1 
      beta, and tumor necrosis factor alpha, and also induces expression of the human 
      immunodeficiency virus type 1 LTR promoter. Little is known about the process by 
      which HHV-6 regulates gene expression.
FAU - Inoue, N
AU  - Inoue N
AD  - Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
FAU - Dambaugh, T R
AU  - Dambaugh TR
FAU - Pellett, P E
AU  - Pellett PE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Infect Agents Dis
JT  - Infectious agents and disease
JID - 9209834
RN  - 0 (Bacterial Proteins)
RN  - 0 (DNA, Viral)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Viral Structural Proteins)
RN  - 0 (replication initiator protein)
RN  - EC 3.6.4.- (DNA Helicases)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/genetics
MH  - Base Sequence
MH  - *DNA Helicases
MH  - DNA Replication
MH  - DNA, Viral/biosynthesis/metabolism
MH  - *DNA-Binding Proteins
MH  - Dependovirus/genetics
MH  - Gene Expression Regulation, Viral
MH  - Genes, Viral
MH  - *Genome, Viral
MH  - Herpesvirus 6, Human/*genetics/pathogenicity
MH  - Humans
MH  - Molecular Sequence Data
MH  - Repetitive Sequences, Nucleic Acid
MH  - *Trans-Activators
MH  - Transcription, Genetic
MH  - Transcriptional Activation
MH  - Viral Structural Proteins/genetics
MH  - Virus Replication
RF  - 145
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 1993/12/01 00:00
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
PHST- 1993/12/01 00:00 [entrez]
PST - ppublish
SO  - Infect Agents Dis. 1993 Dec;2(6):343-60.