PMID- 8013736
OWN - NLM
STAT- MEDLINE
DCOM- 19940725
LR  - 20220408
IS  - 0020-711X (Print)
IS  - 0020-711X (Linking)
VI  - 26
IP  - 4
DP  - 1994 Apr
TI  - Immobilization stress-induced antioxidant defense changes in rat plasma: effect 
      of treatment with reduced glutathione.
PG  - 511-7
AB  - 1. We examined immobilization stress-induced antioxidant defense changes in rat 
      plasma and observed the antioxidant effect of reduced glutathione (GSH) 
      administration on these changes. 2. Immobilization stress induced severe bleeding 
      in the stomach and a significant increase in plasma levels of thiobarbituric acid 
      receives substances (TBARS). 3. Immobilization stress induced a significant 
      decrease in plasma iron-binding, iron-oxidizing protections and radical 
      scavenging activity. 4. Plasma levels of ascorbic acid, ascorbyl radical and 
      superoxide dismutase activity remained unchanged following immobilization stress. 
      5. Treatment with GSH showed a significant protective effect on stomach bleeding, 
      on the increase in plasma TBARS, and on the decrease of iron-binding, 
      iron-oxidizing protection and radical scavenging activity in plasma. 6. These 
      results suggest that immobilization stress induces generation of reactive oxygen 
      species and decreases the endogenous antioxidant defenses, which can be 
      attenuated by extracellular administration of antioxidant GSH.
FAU - Liu, J
AU  - Liu J
AD  - Department of Neuroscience, Okayama University Medical School, Japan.
FAU - Wang, X
AU  - Wang X
FAU - Mori, A
AU  - Mori A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Biochem
JT  - The International journal of biochemistry
JID - 0250365
RN  - 0 (Antioxidants)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - E1UOL152H7 (Iron)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Free Radical Scavengers
MH  - Gastrointestinal Hemorrhage/etiology/prevention & control
MH  - Glutathione/*pharmacology
MH  - Immobilization
MH  - Iron/blood
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reactive Oxygen Species/metabolism
MH  - Stress, Physiological/*blood/*prevention & control
MH  - Superoxide Dismutase/blood
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1016/0020-711x(94)90008-6 [doi]
PST - ppublish
SO  - Int J Biochem. 1994 Apr;26(4):511-7. doi: 10.1016/0020-711x(94)90008-6.