PMID- 8014502
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 170
IP  - 1
DP  - 1994 Jul
TI  - Human herpesvirus 6: a survey of presence and variant distribution in normal 
      peripheral lymphocytes and lymphoproliferative disorders.
PG  - 211-5
AB  - The presence and distribution of human herpesvirus 6 (HHV-6) variants was 
      investigated by polymerase chain reaction in samples from healthy donors and 
      biopsies from non-Hodgkin's lymphomas and Hodgkin's disease. HHV-6 DNA was 
      present in peripheral blood lymphocytes of 17% of healthy donors, variant B three 
      times more frequently than A. HHV-6 was not present in 35 non-Hodgkin's lymphomas 
      of B cell origin and was in only 1 of 10 non-Hodgkin's lymphomas in AIDS 
      patients. HHV-6 DNA was present in 29% of Hodgkin's disease samples; variant B 
      was more frequent than A. Epstein-Barr virus DNA was detected in 38% of Hodgkin's 
      disease biopsies and did not correlate with HHV-6. Thus, the two HHV-6 variants 
      are differently distributed in the healthy population, and the virus probably has 
      no direct role in the development of B cell non-Hodgkin's lymphoma. The detection 
      of HHV-6 DNA in about one-third of Hodgkin's disease biopsies suggests that HHV-6 
      might be associated with a subset of this disorder.
FAU - Di Luca, D
AU  - Di Luca D
AD  - Institute of Microbiology, University of Ferrara, Italy.
FAU - Dolcetti, R
AU  - Dolcetti R
FAU - Mirandola, P
AU  - Mirandola P
FAU - De Re, V
AU  - De Re V
FAU - Secchiero, P
AU  - Secchiero P
FAU - Carbone, A
AU  - Carbone A
FAU - Boiocchi, M
AU  - Boiocchi M
FAU - Cassai, E
AU  - Cassai E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
SB  - IM
MH  - DNA, Viral/genetics/isolation & purification
MH  - Genetic Variation
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Hodgkin Disease/*microbiology
MH  - Humans
MH  - Lymphocytes/*microbiology
MH  - Lymphoma, Non-Hodgkin/*microbiology
MH  - Polymerase Chain Reaction
MH  - Sensitivity and Specificity
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1093/infdis/170.1.211 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Jul;170(1):211-5. doi: 10.1093/infdis/170.1.211.