PMID- 8014525
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 170
IP  - 1
DP  - 1994 Jul
TI  - Enhancement by tumor necrosis factor-alpha of Fc alpha receptor expression and 
      IgA-mediated superoxide generation and killing of Pseudomonas aeruginosa by 
      polymorphonuclear leukocytes.
PG  - 82-7
AB  - Polymorphonuclear leukocytes (PMNL) in bronchoalveolar lavage (BAL) fluid of 
      cystic fibrosis patients express increased levels of receptor for the Fc portion 
      of IgA (Fc alpha R), similar to those found on PMNL stimulated with FMLP in 
      vitro. Since tumor necrosis factor-alpha (TNF alpha) is an activator of PMNL and 
      is found at inflammatory sites, its effects on Fc alpha R expression and 
      IgA-mediated PMNL functions were investigated. Exposure of PMNL to TNF alpha 
      increased surface expression of Fc alpha R 2- to 3-fold, increased superoxide 
      production in response to aggregated IgA 5-fold, and increased phagocytosis of 
      IgA aggregates 3- to 4-fold. Interleukin-8 did not increase Fc alpha R expression 
      and did not enhance IgA-mediated superoxide generation. IgA-dependent PMNL 
      killing of Pseudomonas aeruginosa was enhanced when PMNL were pretreated with TNF 
      alpha. Thus, interactions between phagocytic host defense mechanisms and mucosal 
      IgA may be enhanced by TNF alpha in the inflammatory milieu of the cystic 
      fibrosis lung.
FAU - Hostoffer, R W
AU  - Hostoffer RW
AD  - Dept. of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.
FAU - Krukovets, I
AU  - Krukovets I
FAU - Berger, M
AU  - Berger M
LA  - eng
GR  - DK-27651/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-8)
RN  - 0 (Receptors, Fc)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11062-77-4 (Superoxides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cystic Fibrosis/complications/*immunology
MH  - Humans
MH  - Immunoglobulin A/immunology
MH  - Immunoglobulin G/immunology
MH  - Interleukin-8/pharmacology
MH  - Neutrophils/*immunology/metabolism
MH  - Phagocytosis
MH  - Pseudomonas Infections/complications/*immunology
MH  - Pseudomonas aeruginosa/*immunology
MH  - Receptors, Fc/*biosynthesis
MH  - Superoxides/metabolism
MH  - Tumor Necrosis Factor-alpha/*immunology
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1093/infdis/170.1.82 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Jul;170(1):82-7. doi: 10.1093/infdis/170.1.82.