PMID- 8015728
OWN - NLM
STAT- MEDLINE
DCOM- 19940726
LR  - 20220408
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 165
IP  - 1-2
DP  - 1994 Jan 3
TI  - Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the 
      cerebrospinal fluid from parkinsonian patients.
PG  - 208-10
AB  - Tumor necrosis factor-alpha (TNF-alpha), a glial-cell-related factor, was 
      measured for the first time in the brain (striatum) and cerebrospinal fluid (CSF) 
      from control and parkinsonian patients by a sensitive sandwich enzyme 
      immunoassay. The concentrations of TNF-alpha in the brain and CSF were 
      significantly higher in parkinsonian patients than those in controls. Since 
      TNF-alpha is an important signal transducer of the immune system with cytotoxic 
      and stimulator properties, these results suggest that an immune response may 
      occur in the nigrostriatal dopaminergic regions in Parkinson's disease and that 
      TNF-alpha may be related, at least in part, to the neuronal degeneration.
FAU - Mogi, M
AU  - Mogi M
AD  - Department of Oral Biochemistry, Matsumoto Dental College, Shiojiri, Japan.
FAU - Harada, M
AU  - Harada M
FAU - Riederer, P
AU  - Riederer P
FAU - Narabayashi, H
AU  - Narabayashi H
FAU - Fujita, K
AU  - Fujita K
FAU - Nagatsu, T
AU  - Nagatsu T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Chemistry/*physiology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
MH  - Neostriatum/metabolism
MH  - Nerve Degeneration/physiology
MH  - Parkinson Disease/cerebrospinal fluid/*metabolism
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/cerebrospinal fluid
EDAT- 1994/01/03 00:00
MHDA- 1994/01/03 00:01
CRDT- 1994/01/03 00:00
PHST- 1994/01/03 00:00 [pubmed]
PHST- 1994/01/03 00:01 [medline]
PHST- 1994/01/03 00:00 [entrez]
AID - 0304-3940(94)90746-3 [pii]
AID - 10.1016/0304-3940(94)90746-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1994 Jan 3;165(1-2):208-10. doi: 10.1016/0304-3940(94)90746-3.