PMID- 8017086
OWN - NLM
STAT- MEDLINE
DCOM- 19940722
LR  - 20171116
IS  - 0049-8254 (Print)
IS  - 0049-8254 (Linking)
VI  - 24
IP  - 2
DP  - 1994 Feb
TI  - Ontogenic pattern of carbonyl reductase activity of 11 beta-hydroxysteroid 
      dehydrogenase in mouse liver and kidney.
PG  - 109-17
AB  - 1. The ontogenic pattern of xenobiotic carbonyl reducing activity and 
      glucocorticoid 11 beta-oxidoreducing activity of 11 beta-hydroxysteroid 
      dehydrogenase (11 beta-HSD) in mouse liver and kidney was examined. In addition, 
      the expression of this enzyme was investigated by means of immunoblot analysis in 
      the same tissues. 2. In liver, the foetus shows low or no enzyme activities. 
      After birth both activities increase dramatically with age and remain then on a 
      high plateau until the time of sexual maturity (4 weeks). After maturity, the 
      enzyme activities decline to intermediate values. The developmental pattern of 
      immunological expression of the liver enzyme corresponds well with that of the 
      enzyme activity. 3. Considerable activities of xenobiotic carbonyl reduction and 
      glucocorticoid 11 beta-oxidoreduction are also present after birth in all 
      developmental stages of the kidney. However, no immunological crossreaction was 
      found in any stages with the antibody against the liver 11 beta-HSD suggesting 
      the presence of a structurally different isozyme form in the kidney. 4. The 
      dramatic increase of both activities during the peri- and postnatal developmental 
      periods suggest a potentially biological significance of the liver 11 beta-HSD 
      isozyme in early animal life. 5. Besides being involved in 11 beta-glucocorticoid 
      metabolism in particular the liver enzyme seems to play an additional role as 
      xenobiotic carbonyl reductase.
FAU - Maser, E
AU  - Maser E
AD  - Department of Pharmacology and Toxicology, School of Medicine, 
      Philipps-University, Marburg, Germany.
FAU - Friebertshauser, J
AU  - Friebertshauser J
FAU - Mangoura, S A
AU  - Mangoura SA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Xenobiotica
JT  - Xenobiotica; the fate of foreign compounds in biological systems
JID - 1306665
RN  - EC 1.1.- (Alcohol Oxidoreductases)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.- (Aldo-Keto Reductases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.21 (Aldehyde Reductase)
RN  - EC 1.1.1.n11 (AKR7A5 protein, mouse)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Aging/*metabolism
MH  - Alcohol Oxidoreductases/immunology/*metabolism
MH  - Aldehyde Reductase
MH  - Aldo-Keto Reductases
MH  - Animals
MH  - Cross Reactions
MH  - Hydroxysteroid Dehydrogenases/immunology/*metabolism
MH  - Immunoblotting
MH  - Inactivation, Metabolic
MH  - Kidney/embryology/*enzymology/growth & development
MH  - Liver/embryology/*enzymology/growth & development
MH  - Mice
MH  - Oxidation-Reduction
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.3109/00498259409043225 [doi]
PST - ppublish
SO  - Xenobiotica. 1994 Feb;24(2):109-17. doi: 10.3109/00498259409043225.