PMID- 8021749
OWN - NLM
STAT- MEDLINE
DCOM- 19940802
LR  - 20190920
IS  - 1011-1344 (Print)
IS  - 1011-1344 (Linking)
VI  - 23
IP  - 1
DP  - 1994 Apr
TI  - Hydrophobic Zn(II)-naphthalocyanines as photodynamic therapy agents for Lewis 
      lung carcinoma.
PG  - 35-42
AB  - Four Zn(II) 2,3-naphthalocyanines (unsubstituted ZnNc1, tetracetylamido 
      substituted ZnNc2, tetramino substituted ZnNc3 and tetramethoxy substituted 
      ZnNc4) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine 
      have been injected intra-peritoneally (i.p.) (0.25-0.3 mg kg-1) to male C57/Black 
      mice bearing a transplanted Lewis lung carcinoma. The pharmacokinetic 
      investigations show that three of the four studied ZnNcs, 1, 2 and 4, are good 
      tumor-localizers in Lewis lung carcinoma. The highest concentration is detected 
      after ZnNc1 administration. The lowest tumor concentration as well as the lowest 
      phototherapeutic effect were established with ZnNc3. In previous work it was 
      shown that this ZnNc did not differ from the other three studied ZnNcs regarding 
      the quantum yield of 1O2-formation and the photoinduced electron transfer. 
      Obviously not only the good photochemical properties but also the tumor drug 
      uptake can be an important factor of effective PDT. The biodistribution 
      investigations also show that 72 h after drug injection, the skin concentration 
      of the studied ZnNcs returns to the original base line. Indeed, we can expect 
      that the skin photosensitivity will last for no longer than three days after PDT. 
      The established higher drug concentration in the tumor rather than in the liver 
      tissue (20 h after injection) shows again the tumor targeting selectivity of the 
      applied liposome-sensitiser delivered procedure. Evaluating the PDT effect as 
      reflected in the dynamics of the mean tumor diameter, we obtained unambiguous 
      data on the potential capacity of ZnNcs 1,2,4 as PDT-photosensitisers. The data 
      obtained from the assessment of the cytotoxic effect of PDT on the basis of the 
      degree of induced necrosis, gave an adequate characterization of the tumor tissue 
      destruction.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Shopova, M
AU  - Shopova M
AD  - Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia.
FAU - Wohrle, D
AU  - Wohrle D
FAU - Stoichkova, N
AU  - Stoichkova N
FAU - Milev, A
AU  - Milev A
FAU - Mantareva, V
AU  - Mantareva V
FAU - Muller, S
AU  - Muller S
FAU - Kassabov, K
AU  - Kassabov K
FAU - Georgiev, K
AU  - Georgiev K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 0 (Drug Carriers)
RN  - 0 (Liposomes)
RN  - 0 (Metalloporphyrins)
RN  - 0 (Photosensitizing Agents)
RN  - 2644-64-6 (1,2-Dipalmitoylphosphatidylcholine)
SB  - IM
MH  - 1,2-Dipalmitoylphosphatidylcholine
MH  - Animals
MH  - Cell Differentiation/drug effects
MH  - Cell Division/drug effects
MH  - Drug Carriers
MH  - Endothelium, Vascular/metabolism/pathology
MH  - Lasers
MH  - Liposomes
MH  - Lung Neoplasms/*drug therapy/metabolism/pathology
MH  - Male
MH  - Metalloporphyrins/administration & dosage/pharmacokinetics/*therapeutic use
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Photochemotherapy
MH  - Photosensitizing Agents/*therapeutic use
MH  - Skin/metabolism
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 1011-1344(93)06983-A [pii]
AID - 10.1016/1011-1344(93)06983-a [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 1994 Apr;23(1):35-42. doi: 10.1016/1011-1344(93)06983-a.