PMID- 8021757
OWN - NLM
STAT- MEDLINE
DCOM- 19940729
LR  - 20220409
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 125
IP  - 1
DP  - 1994 Jul
TI  - Human herpesvirus 7: another causal agent for roseola (exanthem subitum).
PG  - 1-5
AB  - Human herpesvirus 7 (HHV-7) was isolated from peripheral blood mononuclear cells 
      of two infants with typical exanthem subitum. The HindIII-, BamHI-, and 
      EcoRI-digested DNA patterns of the isolated viruses were very similar to that of 
      the prototype HHV-7 (RK strain), but different from that of human herpesvirus 6 
      (HHV-6). During the convalescent period of the first patient, the titer of 
      antibody to HHV-7 rose from < 1:10 to 1:320 by an immunofluorescence antibody 
      test, whereas the titer of antibody to HHV-6 remained < 1:10. In the second 
      patient, who had two independent episodes of exanthem subitum during 2 months, 
      both HHV-6 and HHV-7 were sequentially isolated; seroconversion to HHV-6 occurred 
      during the first episode and to HHV-7 during the second episode. In addition, 
      sera from another 15 children who had episodes of exanthem subitum were 
      serologically tested for antibodies to HHV-6 and HHV-7 by immunofluorescence 
      antibody test. Five of seven patients had seroconversion to HHV-7 just after 
      having typical signs and symptoms of exanthem subitum. These results suggest that 
      HHV-7 is one of the causative agents of exanthem subitum.
FAU - Tanaka, K
AU  - Tanaka K
AD  - Department of Pediatrics, Osaka University Medical School, Japan.
FAU - Kondo, T
AU  - Kondo T
FAU - Torigoe, S
AU  - Torigoe S
FAU - Okada, S
AU  - Okada S
FAU - Mukai, T
AU  - Mukai T
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Child, Preschool
MH  - Exanthema Subitum/*microbiology
MH  - Female
MH  - *Herpesviridae Infections/microbiology
MH  - Herpesvirus 6, Human/classification/isolation & purification
MH  - Herpesvirus 7, Human/classification/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Serotyping
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - S0022-3476(94)70113-X [pii]
AID - 10.1016/s0022-3476(94)70113-x [doi]
PST - ppublish
SO  - J Pediatr. 1994 Jul;125(1):1-5. doi: 10.1016/s0022-3476(94)70113-x.