PMID- 8021965
OWN - NLM
STAT- MEDLINE
DCOM- 19940804
LR  - 20131121
IS  - 0098-4108 (Print)
IS  - 0098-4108 (Linking)
VI  - 42
IP  - 3
DP  - 1994 Jul
TI  - Effect of orally administered cadmium on in situ pH, PCO2, and bicarbonate 
      concentration in rat testis and epididymis.
PG  - 323-30
AB  - Acute injections of high doses of cadmium (Cd) induce marked testicular necrosis. 
      However, the effects of low-dose oral Cd exposure, on a chronic basis, are not 
      well documented. The present investigation was designed to examine the effects of 
      such exposure on in situ pH, PCO2, and bicarbonate concentration ([HCO3-]) in the 
      rat testis and epididymis, plasma testosterone levels, and testis and epididymis 
      weights. Male Sprague-Dawley rats were exposed to 50 or 100 ppm Cd for 40 d. Oral 
      administration of 50 or 100 ppm Cd was associated with significant alkalinization 
      of luminal fluid in seminiferous tubules (ST) but did not alter in situ pH values 
      in proximal caput (PCP), middle caput (MCP), or proximal cauda epididymidis 
      (PCD). The in situ PCO2 values in ST, PCP, MCP, and PCD of control animals were 
      indistinguishable from each other and from values after Cd exposure, and all 
      values were significantly higher than system arterial blood (SAB) PCO2. Oral Cd 
      exposure at 50 or 100 ppm did not change the values for bicarbonate in SAB, PCP, 
      or MCP but increased markedly the value in ST. Plasma testosterone levels and 
      testis and epididymis weights were not altered after oral cadmium administration. 
      These findings suggest that, at the doses employed in this study, Cd exposure may 
      result in subtle alterations in the blood-testis barrier and subsequent 
      impairment of acid-base pathways. Furthermore, the traditional view of Cd-related 
      testicular insult based on acute injection protocols needs to be reevaluated in 
      terms of environmental relevance.
FAU - Caflisch, C R
AU  - Caflisch CR
AD  - Department of Internal Medicine, Physiology and Biophysics, University of Texas 
      Medical Branch, Galveston 77555-0562.
LA  - eng
GR  - R01 HD-19988/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Toxicol Environ Health
JT  - Journal of toxicology and environmental health
JID - 7513622
RN  - 0 (Bicarbonates)
RN  - 00BH33GNGH (Cadmium)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Bicarbonates/metabolism
MH  - Cadmium/administration & dosage/*toxicity
MH  - Carbon Dioxide/metabolism
MH  - Epididymis/drug effects
MH  - Hydrogen-Ion Concentration/drug effects
MH  - Male
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seminiferous Tubules/drug effects
MH  - Testis/anatomy & histology/*drug effects/*metabolism
MH  - Testosterone/blood
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1080/15287399409531882 [doi]
PST - ppublish
SO  - J Toxicol Environ Health. 1994 Jul;42(3):323-30. doi: 10.1080/15287399409531882.