PMID- 8025536
OWN - NLM
STAT- MEDLINE
DCOM- 19940810
LR  - 20190830
IS  - 0197-0186 (Print)
IS  - 0197-0186 (Linking)
VI  - 24
IP  - 3
DP  - 1994 Mar
TI  - Accumulation of a 50 kDa N-terminal fragment of beta-APP695 in Alzheimer's 
      disease hippocampus and neocortex.
PG  - 281-8
AB  - Proteolytic processing of beta-amyloid precursor protein (beta-APP) is a key 
      event in the formation of beta-amyloid deposits in Alzheimer's disease (AD) 
      brains and is likely to be accompanied by the accumulation of cleavage products 
      other than the beta/A4 protein. Using a beta-APP695-specific monoclonal antibody 
      in quantitative immunoblotting, a 50 kDa N-terminal fragment of beta-APP695 was 
      detected in neocortex, hippocampus and cerebellum of AD patients and control 
      individuals. The mean level of this fragment was higher in AD hippocampus and 
      neocortex as compared to controls, suggesting that beta-APP695 fragments are 
      generated in various brain regions but that the proteolytic processing is 
      increased in pathologically affected brain areas.
FAU - Loffler, J
AU  - Loffler J
AD  - Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., Basel, 
      Switzerland.
FAU - Langui, D
AU  - Langui D
FAU - Probst, A
AU  - Probst A
FAU - Huber, G
AU  - Huber G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*metabolism
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Antibodies, Monoclonal
MH  - Cerebral Cortex/*metabolism
MH  - Female
MH  - Hippocampus/*metabolism
MH  - Humans
MH  - Immunoblotting
MH  - Male
MH  - Peptide Fragments/*metabolism
EDAT- 1994/03/01 00:00
MHDA- 1994/03/01 00:01
CRDT- 1994/03/01 00:00
PHST- 1994/03/01 00:00 [pubmed]
PHST- 1994/03/01 00:01 [medline]
PHST- 1994/03/01 00:00 [entrez]
AID - 10.1016/0197-0186(94)90086-8 [doi]
PST - ppublish
SO  - Neurochem Int. 1994 Mar;24(3):281-8. doi: 10.1016/0197-0186(94)90086-8.