PMID- 8026074
OWN - NLM
STAT- MEDLINE
DCOM- 19940805
LR  - 20190830
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 78
IP  - 2
DP  - 1994 Apr 15
TI  - A unique neuronal glycolipid defines rostrocaudal compartmentalization in the 
      accessory olfactory system of rats.
PG  - 191-200
AB  - A monoclonal antibody, CC6, reacts with a complex glycolipid whose expression in 
      the rat is restricted to the olfactory system. Structural analysis reveals that 
      the glycolipid contains two alpha-fucose branches; one each at internal and 
      external beta-galactose residues. Immunocytochemistry demonstrates in rat embryos 
      that CC6 glycolipid expression is restricted to a subset of neurons in the 
      vomeronasal organ (VNO) and their corresponding axon projections in the caudal 
      accessory olfactory bulb (AOB). This pattern of expression in the accessory 
      olfactory system is the converse of the pattern revealed by a previously 
      characterized antiglycolipid antibody that reacts with VNO neurons projecting to 
      the rostral AOB. The CC6-reactive glycolipid is also expressed on a subset of 
      neurons in the main olfactory epithelium. Postnatally, axons from these CC6 
      positive sensory neurons converge to form a limited number of axon bundles 
      running longitudinally through the nerve layer of the main olfactory bulb. These 
      data provide further evidence that groups of vomeronasal and olfactory neurons 
      expressing unique surface molecules project axons that terminate in selected 
      targets in the AOB and OB, respectively.
FAU - Schwarting, G A
AU  - Schwarting GA
AD  - Shriver Center, Waltham, MA 02254.
FAU - Drinkwater, D
AU  - Drinkwater D
FAU - Crandall, J E
AU  - Crandall JE
LA  - eng
GR  - DC00953/DC/NIDCD NIH HHS/United States
GR  - HD05515/HD/NICHD NIH HHS/United States
GR  - NS24386/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Glycolipids)
RN  - 28RYY2IV3F (Fucose)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Monoclonal
MH  - Chemoreceptor Cells/*physiology
MH  - Embryo, Mammalian
MH  - Embryonic and Fetal Development
MH  - Epithelial Cells
MH  - Epithelium/physiology
MH  - Fucose/analysis
MH  - Galactose/analysis
MH  - Gestational Age
MH  - Glycolipids/*analysis
MH  - Mice
MH  - Mice, Inbred BALB C/immunology
MH  - Nasal Septum/cytology/*embryology
MH  - Neurons/*cytology/physiology
MH  - Olfactory Bulb/cytology/*embryology
MH  - Olfactory Pathways/cytology/*embryology
MH  - Rats
EDAT- 1994/04/15 00:00
MHDA- 1994/04/15 00:01
CRDT- 1994/04/15 00:00
PHST- 1994/04/15 00:00 [pubmed]
PHST- 1994/04/15 00:01 [medline]
PHST- 1994/04/15 00:00 [entrez]
AID - 0165-3806(94)90026-4 [pii]
AID - 10.1016/0165-3806(94)90026-4 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1994 Apr 15;78(2):191-200. doi: 
      10.1016/0165-3806(94)90026-4.