PMID- 8026801
OWN - NLM
STAT- MEDLINE
DCOM- 19940805
LR  - 20190825
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 16
IP  - 5
DP  - 1994 May
TI  - The total peroxyl radical-trapping ability of plasma and cerebrospinal fluid in 
      normal and preeclamptic parturients.
PG  - 581-90
AB  - Plasma and cerebrospinal fluid total peroxyl radical-trapping antioxidative 
      parameter (TRAP) and the main antioxidant components of TRAP (vitamin E, ascorbic 
      acid, uric acid, protein sulfhydryl groups, and the unidentified antioxidant 
      proportion) were analyzed in 11 preeclamptic parturients, 9 healthy parturients 
      with an uncomplicated pregnancy, and 10 healthy nonpregnant women. In addition, 
      the possible effects of ongoing labor were studied in 10 healthy parturients. The 
      samples of plasma and cerebrospinal fluid (CSF) were collected at cesarean 
      section (pregnant women) or minor surgical procedure (nonpregnant women). Normal 
      pregnancy or ongoing labor induced no significant changes in total TRAP, as 
      compared with nonpregnant women, but significant changes in the percentage 
      contributions of individual antioxidants were noted in plasma and CSF. In 
      preeclampsia, a significant increase in TRAP was noted in both plasma and CSF. 
      This increase was mainly due to an increased proportion of uric acid and 
      unidentified antioxidants in plasma samples, and an increased proportion of 
      unidentified antioxidants in CSF. The concentration of CSF ascorbic acid was 
      decreased in preeclampsia, and a negative correlation between CSF ascorbic acid 
      and blood pressure was observed.
FAU - Uotila, J T
AU  - Uotila JT
AD  - Department of Gynecology and Obstetrics, Tampere University, Finland.
FAU - Kirkkola, A L
AU  - Kirkkola AL
FAU - Rorarius, M
AU  - Rorarius M
FAU - Tuimala, R J
AU  - Tuimala RJ
FAU - Metsa-Ketela, T
AU  - Metsa-Ketela T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Antioxidants)
RN  - 0 (Peroxides)
RN  - 0 (Sulfhydryl Compounds)
RN  - 1406-18-4 (Vitamin E)
RN  - 268B43MJ25 (Uric Acid)
RN  - 3170-83-0 (perhydroxyl radical)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - *Antioxidants
MH  - Ascorbic Acid/blood/cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Labor, Obstetric/blood/cerebrospinal fluid
MH  - Peroxides/*metabolism
MH  - Pre-Eclampsia/*blood/*cerebrospinal fluid
MH  - Pregnancy
MH  - Sulfhydryl Compounds/blood/cerebrospinal fluid
MH  - Uric Acid/blood/cerebrospinal fluid
MH  - Vitamin E/blood/cerebrospinal fluid
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 0891-5849(94)90058-2 [pii]
AID - 10.1016/0891-5849(94)90058-2 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 1994 May;16(5):581-90. doi: 10.1016/0891-5849(94)90058-2.