PMID- 8027232
OWN - NLM
STAT- MEDLINE
DCOM- 19940805
LR  - 20221207
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 79
IP  - 1
DP  - 1994 Jul
TI  - Strong association between HLA-DQA1*0501 and Graves' disease in a male Caucasian 
      population.
PG  - 227-9
AB  - Graves' disease (GD) is an autoimmune thyroid disease and is associated with 
      human leukocyte antigen (HLA)-DR3 and -DQA1*0501 in caucasians. The incidence of 
      GD is 5 times higher in females than in males, possibly due to their greater 
      immune reactivity. Although many attempts have been made to correlate HLA 
      phenotypes and clinical features of GD little attention has been paid to possible 
      heterogeneous HLA distribution among patients of different sexes. To investigate 
      this possibility, 133 (26 males) unrelated caucasian patients with GD and 104 (43 
      males) control subjects were typed for HLA-DRB1, -DQA1, and -DQB1, using 
      sequence-specific oligonucleotide probes to analyze polymerase chain 
      reaction-amplified DNA. There were no significant differences in HLA distribution 
      between male and female controls. The frequencies of HLA-DQA1*0501 were increased 
      in both [88.5%; relative risk (RR) = 9.13; P = 0.000015] and female patients 
      (66.4%; RR = 2.66; P = 0.00046) compared to that in the entire control group 
      (42.3%). The frequencies of DR11 (RR = 2.83; P = 0.019) and DQB1*0301 (RR = 2.50; 
      P = 0.034) were increased only in male patients, whereas that of DR3 was higher 
      in female (RR = 2.39; P = 0.0066) and male (RR = 2.54; not significant, P = 
      0.051) patients, suggesting the possible heterogeneous HLA distribution between 
      the sexes. When the male and female patients were compared, a significant 
      difference was found only for DQA1*0501. The prevalence of DQA1*0501 was 
      significantly higher in males than in females (P = 0.019). As females have 
      augmented immune responsiveness, we speculate that considerable numbers of 
      females may develop GD without a strong HLA susceptibility allele, whereas only a 
      few males develop GD without it.
FAU - Yanagawa, T
AU  - Yanagawa T
AD  - Department of Medicine, University of Chicago, Illinois 60637.
FAU - Mangklabruks, A
AU  - Mangklabruks A
FAU - DeGroot, L J
AU  - DeGroot LJ
LA  - eng
GR  - DK-13377/DK/NIDDK NIH HHS/United States
GR  - DK-27384/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (Oligonucleotide Probes)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/analysis
MH  - Female
MH  - Graves Disease/*immunology
MH  - HLA-DQ Antigens/*analysis/genetics
MH  - HLA-DQ alpha-Chains
MH  - Humans
MH  - Male
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
MH  - *Sex Characteristics
MH  - White People
EDAT- 1994/07/01 00:00
MHDA- 1994/07/01 00:01
CRDT- 1994/07/01 00:00
PHST- 1994/07/01 00:00 [pubmed]
PHST- 1994/07/01 00:01 [medline]
PHST- 1994/07/01 00:00 [entrez]
AID - 10.1210/jcem.79.1.8027232 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1994 Jul;79(1):227-9. doi: 10.1210/jcem.79.1.8027232.