PMID- 8028600
OWN - NLM
STAT- MEDLINE
DCOM- 19940809
LR  - 20190825
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 31
IP  - 9
DP  - 1994 Jun
TI  - Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): 
      restriction map and sequences of new V lambda III genes.
PG  - 657-70
AB  - In order to improve our knowledge of the human immunoglobulin variable lambda 
      locus (IGLV), we mapped one cosmid clone (designated as C40.2) isolated by 
      screening a Colo320HSR genomic library. The 34 kb insert of the C40.2 clone was 
      shown to contain six genes. One gene, IGLV2S1, belongs to the V lambda II 
      subgroup. Four genes belong to the V lambda III subgroup. Two of them, IGLV3S1 
      and IGLV3S2, are potentially functional whereas the two others are pseudogenes. 
      The size of the IGLV3S2 leader intron is four times longer than the classical 
      intron size of 110 bp. The cosmid also contains a vestigial sequence lambda vg2. 
      All these genes share the same orientation of transcription. Pulsed field gel 
      electrophoresis analysis of the IGLV locus shows that most of the V lambda I 
      subgroup genes are located at the 5' end of the locus.
FAU - Frippiat, J P
AU  - Frippiat JP
AD  - Laboratoire d'ImmunoGenetique Moleculaire, LIGM, Institut de Genetique 
      Moleculaire, UMR 9942 CNRS, Universite Montpellier I. France.
FAU - Lefranc, M P
AU  - Lefranc MP
LA  - eng
SI  - GENBANK/X71351
SI  - GENBANK/X71966
SI  - GENBANK/X71967
SI  - GENBANK/X71968
SI  - GENBANK/X74288
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (Immunoglobulin lambda-Chains)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cosmids
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Gene Rearrangement, T-Lymphocyte
MH  - Genes, Immunoglobulin/*genetics
MH  - Genome, Human
MH  - Humans
MH  - Immunoglobulin Variable Region/*genetics
MH  - Immunoglobulin lambda-Chains/*genetics
MH  - Molecular Sequence Data
MH  - Restriction Mapping
MH  - Sequence Analysis
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1016/0161-5890(94)90175-9 [doi]
PST - ppublish
SO  - Mol Immunol. 1994 Jun;31(9):657-70. doi: 10.1016/0161-5890(94)90175-9.