PMID- 8028712 OWN - NLM STAT- MEDLINE DCOM- 19940811 LR - 20190914 IS - 0143-4179 (Print) IS - 0143-4179 (Linking) VI - 26 IP - 4 DP - 1994 Apr TI - Behavioural impairment induced by calcitonin gene-related peptide (CGRP) antiserum in passive avoidance reflex in rats. PG - 233-6 AB - The effects of CGRP antiserum on passive avoidance behaviour were tested in rats. Intracerebroventricular (i.c.v.) administration of CGRP antiserum immediately after a single learning trial attenuated the passive avoidance responses when the animals were tested for 24 h retention. Significant decreases in avoidance latency were found at CGRP antiserum dilutions of 1:20 and 1:40. The data supported the assumption that endogenous brain CGRP may be a modulator in learning-associated memory processes. FAU - Kovacs, A AU - Kovacs A AD - Department of Pathophysiology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary. FAU - Telegdy, G AU - Telegdy G LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Neuropeptides JT - Neuropeptides JID - 8103156 RN - 0 (Immune Sera) RN - JHB2QIZ69Z (Calcitonin Gene-Related Peptide) SB - IM MH - Animals MH - Avoidance Learning/*drug effects MH - Behavior, Animal/*drug effects MH - Calcitonin Gene-Related Peptide/immunology/*physiology MH - Immune Sera/*pharmacology MH - Male MH - Rats EDAT- 1994/04/01 00:00 MHDA- 1994/04/01 00:01 CRDT- 1994/04/01 00:00 PHST- 1994/04/01 00:00 [pubmed] PHST- 1994/04/01 00:01 [medline] PHST- 1994/04/01 00:00 [entrez] AID - 0143-4179(94)90075-2 [pii] AID - 10.1016/0143-4179(94)90075-2 [doi] PST - ppublish SO - Neuropeptides. 1994 Apr;26(4):233-6. doi: 10.1016/0143-4179(94)90075-2.