PMID- 8032886
OWN - NLM
STAT- MEDLINE
DCOM- 19940816
LR  - 20220223
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 642
IP  - 1-2
DP  - 1994 Apr 11
TI  - Rostral-caudal differences in effects of nucleus accumbens amphetamine on VTA 
      ICSS.
PG  - 251-8
AB  - The effects of amphetamine along the rostrocaudal axis of the nucleus accumbens 
      (NAcc) on ventral tegmental area (VTA) intracranial self-stimulation (ICSS) were 
      studied. Eighteen rats were trained to lever press for ICSS in the VTA. 
      Rate-frequency functions were determined by logarithmically decreasing the 
      frequency of cathodal pulses in a stimulation train from a value that induced 
      maximal responding to one that induced no responding (thresholds). After ICSS 
      thresholds stabilized, (+)-amphetamine (20.0 micrograms/0.5 microliter) or its 
      vehicle, distilled H2O (0.5 microliter), were injected directly into the rostral 
      NAcc (n = 6) or the caudal NAcc (n = 8) or the caudate-putamen (CP) (n = 5) just 
      dorsal to the caudal NAcc. Results showed that amphetamine in the caudal NAcc 
      significantly decreased ICSS thresholds without affecting asymptomatic rates of 
      responding, indicating a potentiation of the rewarding efficacy of VTA 
      stimulation. Amphetamine in the rostral NAcc or CP produced smaller, 
      non-significant, decreases in ICSS thresholds. Further analyses revealed a 
      significant positive correlation (r13 = 0.51, P < 0.05) between the site of 
      injection along the rostrocaudal axis of the NAcc and the size of the 
      amphetamine-produced potentiation of VTA stimulation reward. Others have reported 
      topographical differences, including dopamine terminal density and D1 receptor 
      density, in the NAcc. The present results indicate that these anatomical and 
      neurochemical differences appear to be correlated with behavioural differences.
FAU - Ranaldi, R
AU  - Ranaldi R
AD  - Department of Psychology, Queen's University, Kingston, Canada.
FAU - Beninger, R J
AU  - Beninger RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - Electric Stimulation
MH  - Logistic Models
MH  - Male
MH  - Microinjections
MH  - Nucleus Accumbens/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - *Self Stimulation
MH  - Ventral Tegmental Area/*drug effects
EDAT- 1994/04/11 00:00
MHDA- 1994/04/11 00:01
CRDT- 1994/04/11 00:00
PHST- 1994/04/11 00:00 [pubmed]
PHST- 1994/04/11 00:01 [medline]
PHST- 1994/04/11 00:00 [entrez]
AID - 0006-8993(94)90929-6 [pii]
AID - 10.1016/0006-8993(94)90929-6 [doi]
PST - ppublish
SO  - Brain Res. 1994 Apr 11;642(1-2):251-8. doi: 10.1016/0006-8993(94)90929-6.