PMID- 8033549
OWN - NLM
STAT- MEDLINE
DCOM- 19940815
LR  - 20190721
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 30
IP  - 4
DP  - 1994 Apr
TI  - Contact sensitivity to Tinuvin P in mice.
PG  - 226-30
AB  - The contact sensitizing potential of 2-(2'-hydroxy-5'-methylphenyl)benzotriazole 
      (Tinuvin P) was investigated using the murine local lymph node assay (LLNA) and 
      the mouse ear swelling test with some modification in the induction procedure 
      (modified MEST). Topical exposure of the ears to Tinuvin P in acetone:olive oil 
      (AOO) for 3 consecutive days induced no increase in auricular lymph node weight 
      and lymph node cell proliferation. In the LLNA, Tinuvin P was negative, and its 
      sensitizing potential was determined as not strong. In the modified MEST, mice 
      were sensitized with a combination of an intradermal injection of 0.2% Tinuvin P 
      in Freund's complete adjuvant into the shaved abdomen and topical application of 
      1% Tinuvin P in AOO on both ears for 3 consecutive days. The ear thickness in 
      mice previously treated with Tinuvin P increased significantly on challenge with 
      Tinuvin P. A cross-reaction test between Tinuvin P and various substituted 
      benzotriazole ultraviolet light (UV) absorbers was performed. Challenge with 
      these benzotriazole compounds on the ears of the mice previously sensitized to 
      Tinuvin P showed no increase in ear thickness. These data indicated that Tinuvin 
      P had a contact sensitizing ability, while Tinuvin P-sensitized mice did not 
      cross-react with the other benzotriazole UV absorbers.
FAU - Ikarashi, Y
AU  - Ikarashi Y
AD  - Division of Medical Devices, National Institute of Hygienic Sciences, Tokyo, 
      Japan.
FAU - Tsuchiya, T
AU  - Tsuchiya T
FAU - Nakamura, A
AU  - Nakamura A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Triazoles)
RN  - 2440-22-4 (benazol P)
SB  - IM
MH  - Animals
MH  - Cross Reactions
MH  - Dermatitis, Contact/diagnosis/*etiology
MH  - Dermatitis, Irritant/diagnosis/etiology
MH  - Ear, External
MH  - Edema/chemically induced
MH  - Female
MH  - Lymph Nodes/drug effects/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Organ Size/drug effects
MH  - Triazoles/*toxicity
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - 10.1111/j.1600-0536.1994.tb00649.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 1994 Apr;30(4):226-30. doi: 
      10.1111/j.1600-0536.1994.tb00649.x.