PMID- 8034180
OWN - NLM
STAT- MEDLINE
DCOM- 19940817
LR  - 20190914
IS  - 0831-2796 (Print)
IS  - 0831-2796 (Linking)
VI  - 37
IP  - 3
DP  - 1994 Jun
TI  - Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate 
      concentration (Gtpc) to mouse chromosome 9.
PG  - 399-404
AB  - Nine inbred mouse strains surveyed for erythrocytic guanosine-5'-triphosphate 
      (GTP) concentration were found to segregate into two discrete groups. Strains 
      having low GTP levels between 1.4 and 3.4 nmol/10(9) cells were C3H/HeJ, 
      C3H/HeHa, A/J, and WB/ReJ. Strains having high GTP levels between 11.0 and 14.8 
      nmol/10(9) cells were AKR/J, DBA/2J, CBA/J, C57BL/6J, and C57L/J. Erythrocytic 
      ATP levels did not vary significantly among these groups. Crosses between low and 
      high GTP strains gave F1 progeny having intermediate levels of GTP, and the 
      progeny of F1's backcrossed to parental strains segregated in a 1:1 ratio for GTP 
      concentration. We designated the GTP concentration determining trait, Gtpc. 
      Typing the C57BL/6J x C3H/HeJ (B x H) recombinant inbred strains for GTP levels 
      revealed 0/12 strain distribution pattern differences for loci on both 
      chromosomes 5 and 9. Backcross analysis did not provide evidence for linkage of 
      Gtpc to W (dominant white spotting) on chromosome 5 with 15/45 recombinants. A 
      test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of 
      linkage with an observed recombination frequency of 14.6 +/- 5.5 and a 99% 
      confidence interval of 3.9-33.9 cM.
FAU - Jenuth, J P
AU  - Jenuth JP
AD  - Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada.
FAU - Fung, E
AU  - Fung E
FAU - Snyder, F F
AU  - Snyder FF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Genome
JT  - Genome
JID - 8704544
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
GS  - Bg1
GS  - Emv-1
GS  - En-2
GS  - Fv-2
GS  - Gtpc
GS  - Ltw-3
GS  - Mpmv-13
GS  - Pmv-5
GS  - Qdpr
GS  - Ras12-2
GS  - kfo-1
GS  - mod-1
MH  - Adenosine Triphosphate/blood
MH  - Animals
MH  - *Chromosome Mapping
MH  - Crosses, Genetic
MH  - Erythrocytes/*metabolism
MH  - Female
MH  - Guanosine Triphosphate/*blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred AKR/genetics
MH  - Mice, Inbred C3H/genetics
MH  - Mice, Inbred C57BL/genetics
MH  - Mice, Inbred CBA/genetics
MH  - Mice, Inbred DBA/genetics
MH  - Mice, Inbred Strains/*genetics
MH  - Recombination, Genetic
MH  - Species Specificity
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.1139/g94-056 [doi]
PST - ppublish
SO  - Genome. 1994 Jun;37(3):399-404. doi: 10.1139/g94-056.