PMID- 8034312
OWN - NLM
STAT- MEDLINE
DCOM- 19940818
LR  - 20071114
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 20
IP  - 3
DP  - 1994 Apr
TI  - Chromosomal localization of the human retinoid X receptors.
PG  - 397-403
AB  - The recently described retinoid X receptors (RXRs) respond to the novel retinoid 
      9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, 
      thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In 
      this work, we report high-resolution localization of the human RXR genes within 
      cytogenetic bands and also within a standard reference map of cosmid DNA markers 
      on human chromosomes. We have determined the location of the human RXR genes by 
      pairwise hybridization of the RXR cosmids and reference markers, using 
      fluorescence in situ hybridization. We localized (i) RXR alpha (RXRA) to 
      chromosome 9 band q34.3; (ii) RXR beta (RXRB) to chromosome 6 band 21.3; and 
      (iii) RXR gamma (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive 
      transcription factors have been identified so far, including three retinoic acid 
      receptors in addition to the three RXRs. Interestingly, each of these receptors 
      in human and mouse is encoded by genes located at distinct chromosomal loci and 
      on separate chromosomes. The proximity of RXR genes to loci known to be 
      associated with genetic disorders suggests that their location may be useful in 
      establishing a link between RXRs and certain human diseases.
FAU - Almasan, A
AU  - Almasan A
AD  - Salk Institute for Biological Studies, La Jolla, California 92037.
FAU - Mangelsdorf, D J
AU  - Mangelsdorf DJ
FAU - Ong, E S
AU  - Ong ES
FAU - Wahl, G M
AU  - Wahl GM
FAU - Evans, R M
AU  - Evans RM
LA  - eng
GR  - HG00202/HG/NHGRI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
GS  - RARA
GS  - RARB
GS  - RARG
GS  - RXRA
GS  - RXRB
GS  - RXRG
GS  - Rara
GS  - Rarb
GS  - Rarg
GS  - Rxra
GS  - Rxrb
GS  - Rxrg
MH  - Animals
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 6
MH  - *Chromosomes, Human, Pair 9
MH  - Cosmids
MH  - Genetic Markers
MH  - Hominidae/*genetics
MH  - Humans
MH  - Mice/genetics
MH  - Nuclear Proteins/genetics
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - *Receptors, Retinoic Acid
MH  - Retinoid X Receptors
MH  - Transcription Factors/metabolism
EDAT- 1994/04/01 00:00
MHDA- 1994/04/01 00:01
CRDT- 1994/04/01 00:00
PHST- 1994/04/01 00:00 [pubmed]
PHST- 1994/04/01 00:01 [medline]
PHST- 1994/04/01 00:00 [entrez]
AID - S0888-7543(84)71193-1 [pii]
AID - 10.1006/geno.1994.1193 [doi]
PST - ppublish
SO  - Genomics. 1994 Apr;20(3):397-403. doi: 10.1006/geno.1994.1193.