PMID- 8035043
OWN - NLM
STAT- MEDLINE
DCOM- 19940818
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 170
IP  - 2
DP  - 1994 Aug
TI  - Pentoxifylline aggravates impairment in tumor necrosis factor-alpha secretion and 
      increases mycobacterial load in macrophages from AIDS patients with disseminated 
      Mycobacterium avium-intracellulare complex infection.
PG  - 484-7
AB  - Pentoxifylline, which inhibits tumor necrosis factor-alpha (TNF alpha), decreases 
      human immunodeficiency virus replication in peripheral blood mononuclear cells. 
      However, TNF alpha is important in cellular defense against M. 
      avium-intracellulare complex (MAC), a common infection in advanced AIDS. The 
      effect of pentoxifylline on mycobacterial colony counts in macrophages with in 
      vivo MAC infection was evaluated, and differences in lipopolysaccharide 
      (LPS)-induced TNF release in infected and uninfected macrophages were determined. 
      Macrophages with in vivo MAC infection released much less TNF alpha in response 
      to LPS (P = .01). The response was partially restored after antimycobacterial 
      therapy. Pentoxifylline, in a concentration that inhibited LPS-induced TNF alpha 
      by 52.4%, increased MAC counts by 2.5- to 50.0-fold. Thus, macrophages from AIDS 
      patients with disseminated MAC infection are deficient in their ability to 
      release TNF alpha, and further inhibition by pentoxifylline may be detrimental.
FAU - Sathe, S S
AU  - Sathe SS
AD  - Div. of Infectious Diseases, Brooklyn VA Medical Center, NY 11209.
FAU - Sarai, A
AU  - Sarai A
FAU - Tsigler, D
AU  - Tsigler D
FAU - Nedunchezian, D
AU  - Nedunchezian D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/drug therapy/*immunology
MH  - Acquired Immunodeficiency Syndrome/drug therapy
MH  - Colony Count, Microbial
MH  - Humans
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophages/*drug effects/immunology/microbiology
MH  - Mycobacterium avium Complex/*drug effects/growth & development/immunology
MH  - Mycobacterium avium-intracellulare Infection/drug therapy/*immunology
MH  - Pentoxifylline/*adverse effects/therapeutic use
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors/*metabolism
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
AID - 10.1093/infdis/170.2.484 [doi]
PST - ppublish
SO  - J Infect Dis. 1994 Aug;170(2):484-7. doi: 10.1093/infdis/170.2.484.