PMID- 8035901
OWN - NLM
STAT- MEDLINE
DCOM- 19940812
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 33
IP  - 2
DP  - 1994 Feb
TI  - Effects of mu and delta opioid receptor agonists and antagonists on absence 
      epilepsy in WAG/Rij rats.
PG  - 161-6
AB  - The effects of various types of opioid receptor agonists and antagonists were 
      determined in a genetic rat model for generalized absence epilepsy. Rats of the 
      WAG/Rij strain spontaneously showed several hundred spike-wave discharges per 
      day. Intracerebroventricular (i.c.v.) injections of the selective mu agonist 
      DAMGO (0.2, 0.7 microgram) resulted in a dose-related increase in the number of 
      spike-wave discharges, while the selective delta agonist DPDPE (20, 60 
      micrograms) was without effect. DAMGO reduced the duration of automatic behavior, 
      enhanced the immobile behavior (after the low dose) and had no effect on 
      exploratory behavior. On the other hand, DPDPE significantly enhanced the total 
      time spent on exploration, but did not influence other behavioral parameters. 
      There was no correlation between the ability to the drug to modulate the 
      epileptic activity and behavioral changes. The nonselective antagonist naloxone, 
      administered either i.p. (0.4, 2.0, 10 mg/kg) or i.c.v. (10, 50 micrograms), 
      increased the number of spike-wave discharges in a dose-dependent way. The 
      specific delta receptor antagonist naltrindole (0.3, 1 mg/kg) was without effect, 
      as was the irreversible mu receptor antagonist beta-funaltrexamine (beta-FNA). 
      Pretreatment with beta-FNA diminished the action of DAMGO. These results clearly 
      indicate that activation of the mu opioid receptor increases the number of 
      spike-wave discharges, and that modulation of delta receptors is not effective. 
      On the other hand, the naloxone-induced enhancement of spike-wave discharges, 
      suggests a tonic control of the epileptic activity by another opioid system. 
      These results point to an important role of the mu-, but not delta-, receptor in 
      facilitation of the epileptic activity in WAG/Rij rats.
FAU - Lason, W
AU  - Lason W
AD  - Neuropeptide Research Department, Institute of Pharmacology, Polish Academy of 
      Sciences, Krakow.
FAU - Przewlocka, B
AU  - Przewlocka B
FAU - Coenen, A
AU  - Coenen A
FAU - Przewlocki, R
AU  - Przewlocki R
FAU - Van Luijtelaar, G
AU  - Van Luijtelaar G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Enkephalins)
RN  - 0 (Receptors, Opioid, delta)
RN  - 0 (Receptors, Opioid, mu)
RN  - 100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
RN  - 36B82AMQ7N (Naloxone)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Brain/drug effects/physiopathology
MH  - Electroencephalography
MH  - Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
MH  - Enkephalin, D-Penicillamine (2,5)-
MH  - Enkephalins/pharmacology
MH  - Epilepsy, Absence/*physiopathology
MH  - Male
MH  - Naloxone/pharmacology
MH  - Rats
MH  - Receptors, Opioid, delta/antagonists & inhibitors/*drug effects
MH  - Receptors, Opioid, mu/antagonists & inhibitors/*drug effects
EDAT- 1994/02/01 00:00
MHDA- 1994/02/01 00:01
CRDT- 1994/02/01 00:00
PHST- 1994/02/01 00:00 [pubmed]
PHST- 1994/02/01 00:01 [medline]
PHST- 1994/02/01 00:00 [entrez]
AID - 10.1016/0028-3908(94)90003-5 [doi]
PST - ppublish
SO  - Neuropharmacology. 1994 Feb;33(2):161-6. doi: 10.1016/0028-3908(94)90003-5.