PMID- 80382
OWN - NLM
STAT- MEDLINE
DCOM- 19781202
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 21
IP  - 2
DP  - 1978 Aug
TI  - Significance of noncapsular antigens in protection against experimental 
      Haemophilus influenzae type b disease: cross-reactivity.
PG  - 619-26
AB  - A bacterial strain, tentatively identified as an Actinobacillus species, was 
      found to asymptomatically colonize the pharynx of some rats and to bear cell wall 
      antigens which cross-react with noncapsular antigens of Haemophilus influenzae 
      type b (HIb). The cross-reacting antigens appeared to be a heterogeneous mixture 
      with varying molecular size and charge. The antigenic moieties are probably 
      carbohydrate in nature. Antisera raised with this strain had both immunochemical 
      and biological (bactericidal, opsonizing, and protective against experimental 
      infection) activity against HIb. These findings lend further evidence to the idea 
      that noncapsular antigens are important in the induction of resistance to HIb 
      disease. The findings also raise the possibility of using bacteria which 
      cross-react with noncapsular antigens for immunization against HIb disease in 
      humans through nasopharyngeal or enteric colonization.
FAU - Myerowitz, R L
AU  - Myerowitz RL
FAU - Norden, C W
AU  - Norden CW
FAU - Demchak, T A
AU  - Demchak TA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Epitopes)
RN  - 0 (Immune Sera)
SB  - IM
MH  - Animals
MH  - *Antigens, Bacterial/isolation & purification
MH  - Chromatography, DEAE-Cellulose
MH  - *Cross Reactions
MH  - Epitopes
MH  - Haemophilus Infections/*immunology/prevention & control
MH  - Haemophilus influenzae/immunology
MH  - Immune Sera/pharmacology
MH  - Rabbits
MH  - Rats
PMC - PMC422038
EDAT- 1978/08/01 00:00
MHDA- 1978/08/01 00:01
PMCR- 1978/08/01
CRDT- 1978/08/01 00:00
PHST- 1978/08/01 00:00 [pubmed]
PHST- 1978/08/01 00:01 [medline]
PHST- 1978/08/01 00:00 [entrez]
PHST- 1978/08/01 00:00 [pmc-release]
AID - 10.1128/iai.21.2.619-626.1978 [doi]
PST - ppublish
SO  - Infect Immun. 1978 Aug;21(2):619-26. doi: 10.1128/iai.21.2.619-626.1978.