PMID- 8040076
OWN - NLM
STAT- MEDLINE
DCOM- 19940822
LR  - 20190723
IS  - 0021-8820 (Print)
IS  - 0021-8820 (Linking)
VI  - 47
IP  - 6
DP  - 1994 Jun
TI  - Suppressive effect of cyclosporin A on delayed-type hypersensitivity to syngeneic 
      testicular cells.
PG  - 708-14
AB  - We have investigated the immunosuppressive effect of cyclosporin A (CsA) on 
      delayed-type hypersensitivity (DTH) to syngeneic testicular cells (TC). DTH to 
      syngeneic TC was induced by subcutaneous (sc) immunization with viable syngeneic 
      TC and was augmented by a high dose of cyclophosphamide (CY)-pretreatment. DTH 
      was suppressed by administration of CsA in a dose-dependent manner. When the mice 
      were immunized alone or with 100 mg/kg of CY-pretreatment, 30 mg/kg or more of 
      CsA suppressed DTH to TC. In mice immunized with 200 mg/kg of CY-pretreatment, 50 
      mg/kg of CsA was needed to suppress DTH. DTH is thought to play a key role in the 
      induction and/or maintenance of experimental autoimmune orchitis (EAO). Our data 
      show that DTH to syngeneic TC induced by immunization is suppressed by 
      administration of CsA. Pretreatment of mice with immunization and administration 
      of CsA suppressed DTH significantly when the mice were challenged with 
      immunization with CY-pretreatment. However, DTH was rather enhanced significantly 
      in mice pretreated with administration of CsA alone without preimmunization. 
      Therefore, even though administration of CsA with immunization suppresses DTH, 
      administration of CsA alone might rather eliminate suppressive mechanism 
      resulting in augmentation of DTH.
FAU - Sakamoto, Y
AU  - Sakamoto Y
AD  - Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
FAU - Matsumoto, T
AU  - Matsumoto T
FAU - Kumazawa, J
AU  - Kumazawa J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Antibiot (Tokyo)
JT  - The Journal of antibiotics
JID - 0151115
RN  - 0 (Autoantigens)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Animals
MH  - Autoantigens/drug effects/*immunology
MH  - Cells, Cultured
MH  - Cyclophosphamide/pharmacology
MH  - Cyclosporine/pharmacology/*therapeutic use
MH  - Dose-Response Relationship, Immunologic
MH  - Hypersensitivity, Delayed/*drug therapy
MH  - Immune Tolerance
MH  - Liver/cytology/immunology
MH  - Male
MH  - Mice
MH  - Testis/cytology/*immunology
EDAT- 1994/06/01 00:00
MHDA- 1994/06/01 00:01
CRDT- 1994/06/01 00:00
PHST- 1994/06/01 00:00 [pubmed]
PHST- 1994/06/01 00:01 [medline]
PHST- 1994/06/01 00:00 [entrez]
AID - 10.7164/antibiotics.47.708 [doi]
PST - ppublish
SO  - J Antibiot (Tokyo). 1994 Jun;47(6):708-14. doi: 10.7164/antibiotics.47.708.