PMID- 8046338
OWN - NLM
STAT- MEDLINE
DCOM- 19940830
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 180
IP  - 2
DP  - 1994 Aug 1
TI  - Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 
      8.2+CD4+8- murine thymocytes positively selected by class I molecules.
PG  - 653-61
AB  - We analyzed the phenotype and V beta-T cell receptor (TCR) repertoire, together 
      with interleukin 7 receptor (IL-7R) expression in unfractionated thymocytes 
      stimulated in vitro with IL-7. This culture system results in a specific 
      proliferation of mature thymocytes belonging to the CD3+CD4-, CD4+8-, and CD4-8+ 
      subsets. IL-7 induced a preferential expansion of V beta 8.2+CD4-8- and V beta 
      8.2+CD4-8- thymocytes. This phenomenon is not observed in beta 
      2-microglobulin-deficient mice, showing that a fraction of CD4+8- thymocytes, 
      enriched in V beta 8.2+ cells, is selected by class I molecules in normal mice, 
      as are a large proportion of CD4-8- alpha beta TCR+ thymocytes. Our findings also 
      establish that IL-7 plays a major role in the expansion of rare thymocyte 
      subsets, which could exert important functions in inflammatory and immune 
      responses.
FAU - Vicari, A
AU  - Vicari A
AD  - INSERM U345, Institut Necker, Paris, France.
FAU - de Moraes, M do C
AU  - de Moraes Mdo C
FAU - Gombert, J M
AU  - Gombert JM
FAU - Dy, M
AU  - Dy M
FAU - Penit, C
AU  - Penit C
FAU - Papiernik, M
AU  - Papiernik M
FAU - Herbelin, A
AU  - Herbelin A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Interleukin-7)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-7)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Animals
MH  - CD4 Antigens/*immunology
MH  - CD8 Antigens/*immunology
MH  - Cells, Cultured
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Interleukin-7/*physiology
MH  - Lymphocyte Activation
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Phenotype
MH  - Receptors, Antigen, T-Cell, alpha-beta/*immunology
MH  - Receptors, Interleukin/metabolism
MH  - Receptors, Interleukin-7
MH  - T-Lymphocyte Subsets/*immunology
MH  - T-Lymphocytes/*immunology
MH  - Thymus Gland/cytology/immunology
MH  - beta 2-Microglobulin/immunology
PMC - PMC2191612
EDAT- 1994/08/01 00:00
MHDA- 1994/08/01 00:01
PMCR- 1995/02/01
CRDT- 1994/08/01 00:00
PHST- 1994/08/01 00:00 [pubmed]
PHST- 1994/08/01 00:01 [medline]
PHST- 1994/08/01 00:00 [entrez]
PHST- 1995/02/01 00:00 [pmc-release]
AID - 94321920 [pii]
AID - 10.1084/jem.180.2.653 [doi]
PST - ppublish
SO  - J Exp Med. 1994 Aug 1;180(2):653-61. doi: 10.1084/jem.180.2.653.