PMID- 8047297
OWN - NLM
STAT- MEDLINE
DCOM- 19940901
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 169
IP  - 1-2
DP  - 1994 Mar 14
TI  - Increase in extracellular NCAM and amyloid precursor protein following induction 
      of long-term potentiation in the dentate gyrus of anaesthetized rats.
PG  - 77-80
AB  - The extracellular concentrations of the amyloid precursor protein (APP) and 
      neural-cell adhesion molecule (NCAM) in the dentate gyrus of the anaesthetized 
      rat were assayed before and after the induction of long-term potentiation (LTP) 
      in vivo. Levels of high molecular weight neurofilament protein and activity of 
      the lysosomal enzyme arylsulphatase were measured as internal controls and 
      indicators of neuronal damage. Ninety minutes after the induction of LTP, the 
      concentrations of NCAM and APP increased, in an NMDA-dependent manner, in the 
      absence of changes in neurofilament and arylsulphatase levels. The delayed 
      changes in the extracellular concentration of these molecules may reflect events 
      leading to morphological modifications following LTP.
FAU - Fazeli, M S
AU  - Fazeli MS
AD  - Department of Experimental Pathology, UMDS, Guy's Hospital, London, UK.
FAU - Breen, K
AU  - Breen K
FAU - Errington, M L
AU  - Errington ML
FAU - Bliss, T V
AU  - Bliss TV
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Neurofilament Proteins)
RN  - EC 3.1.6.- (Sulfatases)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*biosynthesis
MH  - Anesthesia
MH  - Animals
MH  - Blotting, Western
MH  - Cell Adhesion Molecules, Neuronal/*biosynthesis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Extracellular Matrix/metabolism
MH  - Hippocampus/*metabolism/physiology
MH  - Immunoblotting
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Neurofilament Proteins/biosynthesis/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stereotaxic Techniques
MH  - Sulfatases/biosynthesis/metabolism
EDAT- 1994/03/14 00:00
MHDA- 1994/03/14 00:01
CRDT- 1994/03/14 00:00
PHST- 1994/03/14 00:00 [pubmed]
PHST- 1994/03/14 00:01 [medline]
PHST- 1994/03/14 00:00 [entrez]
AID - 0304-3940(94)90360-3 [pii]
AID - 10.1016/0304-3940(94)90360-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1994 Mar 14;169(1-2):77-80. doi: 10.1016/0304-3940(94)90360-3.