PMID- 8048929
OWN - NLM
STAT- MEDLINE
DCOM- 19940901
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 202
IP  - 2
DP  - 1994 Jul 29
TI  - cDNA cloning and functional expression of a human monocyte chemoattractant 
      protein 1 receptor.
PG  - 1156-62
AB  - A novel human G-protein-coupled seven-transmembrane-type receptor gene, 24-1, has 
      been cloned from THP-1 cells. The 24-1 was 56% and 34% identical to the 
      macrophage inflammatory protein-1 alpha (MIP-1 alpha) receptor and the 
      interleukin-8 (IL-8) receptors at the amino acid level, respectively. To examine 
      the ligand specificity of the receptor, we have established a stable transfectant 
      of this gene with human kidney 293 cells. Monocyte chemoattractant protein-1 
      (MCP-1) induced a rapid increase of Ca++ influx in the 24-1-transfectant, while 
      other C-C chemokines tested did not. This indicates that the 24-1 encodes the 
      human MCP-1 receptor.
FAU - Yamagami, S
AU  - Yamagami S
AD  - Pharmaceutical Discovery Research Laboratories, Teijin Institute for Biomedical 
      Research, Tokyo, Japan.
FAU - Tokuda, Y
AU  - Tokuda Y
FAU - Ishii, K
AU  - Ishii K
FAU - Tanaka, H
AU  - Tanaka H
FAU - Endo, N
AU  - Endo N
LA  - eng
SI  - GENBANK/D29984
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acid Sequence
MH  - Calcium/metabolism
MH  - Cell Line
MH  - Chemokine CCL2
MH  - Chemotactic Factors/pharmacology
MH  - *Cloning, Molecular
MH  - DNA Probes
MH  - DNA, Complementary/*genetics
MH  - GTP-Binding Proteins/physiology
MH  - *Gene Expression
MH  - Humans
MH  - Kidney
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Plasmids
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/metabolism
MH  - Receptors, CCR2
MH  - *Receptors, Chemokine
MH  - Receptors, Cytokine/chemistry/*genetics
MH  - Transfection
EDAT- 1994/07/29 00:00
MHDA- 1994/07/29 00:01
CRDT- 1994/07/29 00:00
PHST- 1994/07/29 00:00 [pubmed]
PHST- 1994/07/29 00:01 [medline]
PHST- 1994/07/29 00:00 [entrez]
AID - S0006-291X(84)72049-3 [pii]
AID - 10.1006/bbrc.1994.2049 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1994 Jul 29;202(2):1156-62. doi: 
      10.1006/bbrc.1994.2049.