PMID- 8048940
OWN - NLM
STAT- MEDLINE
DCOM- 19940901
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 202
IP  - 2
DP  - 1994 Jul 29
TI  - Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell 
      proliferation and migration.
PG  - 701-9
AB  - Various peptide growth factors have been found to regulate epithelial cell 
      function within the mucosal epithelium of the gastrointestinal tract. In this 
      study hepatocyte growth factor/scatter factor (HGF/SF) was found to stimulate 
      intestinal epithelial cell proliferation: 2.5-fold in the non-transformed rat 
      small intestinal epithelial cell line IEC-6 and 1.9-fold in the human colon 
      cancer-derived HT-29 cell line. In addition, HGF/SF enhanced epithelial cell 
      restitution, the initial step involved in gastrointestinal wound healing, in an 
      in vitro model. Migration of IEC-6 in wounded monolayers was enhanced up to 
      7-fold. Enhancement of restitution by HGF could be completely abrogated by 
      addition of immunoneutralizing anti-TGF beta 1, indicating that this process is 
      mediated through a TGF beta-dependent pathway. These findings suggest that HGF 
      exerts functional effects on intestinal epithelial cell populations and may play 
      a role in the morphogenesis of the gastrointestinal tract and its remodeling 
      following injury.
FAU - Dignass, A U
AU  - Dignass AU
AD  - Department of Medicine, Massachusetts General Hospital, Boston 02114.
FAU - Lynch-Devaney, K
AU  - Lynch-Devaney K
FAU - Podolsky, D K
AU  - Podolsky DK
LA  - eng
GR  - DK-41557/DK/NIDDK NIH HHS/United States
GR  - DK-43351/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transforming Growth Factor beta)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - *Cell Division
MH  - Cell Line
MH  - *Cell Movement
MH  - Colonic Neoplasms
MH  - Epithelial Cells
MH  - Hepatocyte Growth Factor/*pharmacology
MH  - Humans
MH  - Intestines/*cytology
MH  - Rats
MH  - Recombinant Proteins/pharmacology
MH  - Transforming Growth Factor beta/pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1994/07/29 00:00
MHDA- 1994/07/29 00:01
CRDT- 1994/07/29 00:00
PHST- 1994/07/29 00:00 [pubmed]
PHST- 1994/07/29 00:01 [medline]
PHST- 1994/07/29 00:00 [entrez]
AID - S0006291X84719875 [pii]
AID - 10.1006/bbrc.1994.1987 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1994 Jul 29;202(2):701-9. doi: 
      10.1006/bbrc.1994.1987.