PMID- 8052162
OWN - NLM
STAT- MEDLINE
DCOM- 19940906
LR  - 20190821
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 38
IP  - 1
DP  - 1994
TI  - Increase in T-cells bearing CD25 in bronchoalveolar lavage fluid from HAM/TSP 
      patients and HTLV-I carriers.
PG  - 55-62
AB  - To determine the immunologic characteristics of T-cells in local pulmonary 
      lesions of human T-cell lymphotropic virus type I (HTLV-I) carriers, we 
      investigated lymphocyte surface markers in peripheral blood and bronchoalveolar 
      lavage fluid (BALF) of 38 HTLV-I carriers, 8 HTLV-I associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP) patients, 44 HTLV-I 
      seronegative patients with pulmonary diseases and 7 healthy volunteers using 
      two-color flow cytometric analysis. In peripheral blood, activated T-cells, 
      CD4+HLA-DR+, CD8+HLA-DR+ and CD3+CD25+, and CD4+CD29+ cells increased 
      significantly in carriers and HAM/TSP patients compared with healthy volunteers 
      and seronegative patients. In BALF, T-cells, especially CD25+ cells, increased 
      significantly in carriers and HAM/TSP patients, compared with healthy volunteers 
      and seronegative patients. These findings indicated that T-cells in the lungs, as 
      well as in peripheral blood, are activated in carriers and HAM/TSP patients. 
      Interestingly, there was dissociation between expression of CD3+CD25+ cells in 
      BALF and peripheral blood from these patients. These results suggest that T-cells 
      activated probably by HTLV-I accumulate in the lungs in some carriers and HAM/TSP 
      patients, and HTLV-I may be involved in the immunologic dysfunction in the lungs 
      of these patients. However, we did not find any correlation between the degree of 
      clinical features and the elevation of CD3+CD25+ cells in BALF, or its 
      characteristic features on chest roentgenograms.
FAU - Mukae, H
AU  - Mukae H
AD  - Third Department of Internal Medicine, Miyazaki Medical College, Japan.
FAU - Kohno, S
AU  - Kohno S
FAU - Morikawa, N
AU  - Morikawa N
FAU - Kadota, J
AU  - Kadota J
FAU - Matsukura, S
AU  - Matsukura S
FAU - Hara, K
AU  - Hara K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (CD3 Complex)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Aged
MH  - Bronchoalveolar Lavage Fluid/*cytology/immunology
MH  - CD3 Complex/analysis
MH  - Carrier State/blood/*immunology
MH  - Female
MH  - Flow Cytometry/methods
MH  - HLA-DR Antigens/analysis
MH  - HTLV-I Infections/blood/*immunology
MH  - Humans
MH  - Lung/immunology/microbiology
MH  - Lung Diseases/blood/immunology
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/blood/*immunology
MH  - Polymerase Chain Reaction
MH  - Receptors, Interleukin-2/*analysis
MH  - T-Lymphocyte Subsets/*immunology
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
AID - 10.1111/j.1348-0421.1994.tb01744.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1994;38(1):55-62. doi: 10.1111/j.1348-0421.1994.tb01744.x.