PMID- 8053150
OWN - NLM
STAT- MEDLINE
DCOM- 19940908
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 203
IP  - 2
DP  - 1994 Sep
TI  - Identification of a new group of bovine viral diarrhea virus strains associated 
      with severe outbreaks and high mortalities.
PG  - 260-8
AB  - New BVDV strains associated with very high mortalities, which killed about 25% of 
      the veal calves in Quebec in 1993, have been isolated. In this study, 
      characterization of the last two-thirds of the 5' untranslated region (5'UTR) of 
      their genome and virus neutralization experiments with polyvalent antisera raised 
      in different animals both demonstrated that these strains formed a distinct 
      group. Despite a difference of about 25% in the 5'UTR sequence with that of the 
      classical strains, these 5'UTRs maintained the same secondary structure albeit 
      with a higher stability. Serological crossreactivity between the classical and 
      new BVDV strains was relatively low and suggest that new strains should also be 
      included to obtain efficient BVDV vaccines. Based upon the distinct 
      characteristics of these new BVDV strains, we propose to divide BVDV into two 
      groups. Group I comprises the classical BVDV isolates including commonly used 
      laboratory and vaccine strains, and group II comprises the newly described BVDV 
      strains and those associated with thrombocytopenia and hemorrhaging.
FAU - Pellerin, C
AU  - Pellerin C
AD  - Institut Armand-Frappier, Centre de recherche en virologie, Laval, Quebec, 
      Canada.
FAU - van den Hurk, J
AU  - van den Hurk J
FAU - Lecomte, J
AU  - Lecomte J
FAU - Tijssen, P
AU  - Tijssen P
LA  - eng
SI  - GENBANK/L32875
SI  - GENBANK/L32876
SI  - GENBANK/L32877
SI  - GENBANK/L32878
SI  - GENBANK/L32879
SI  - GENBANK/L32880
SI  - GENBANK/L32881
SI  - GENBANK/L32882
SI  - GENBANK/L32883
SI  - GENBANK/L32884
SI  - GENBANK/L32885
SI  - GENBANK/L32886
SI  - GENBANK/L32887
SI  - GENBANK/L32888
SI  - GENBANK/L32889
SI  - GENBANK/L32890
SI  - GENBANK/L32891
SI  - GENBANK/L32892
SI  - GENBANK/L32893
SI  - GENBANK/L32894
SI  - GENBANK/L32895
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Immune Sera)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Bovine Virus Diarrhea-Mucosal Disease/epidemiology/*microbiology/mortality
MH  - Cattle
MH  - Disease Outbreaks
MH  - Immune Sera/immunology
MH  - Molecular Sequence Data
MH  - Nucleic Acid Conformation
MH  - Pestivirus/genetics/immunology/*isolation & purification
EDAT- 1994/09/01 00:00
MHDA- 1994/09/01 00:01
CRDT- 1994/09/01 00:00
PHST- 1994/09/01 00:00 [pubmed]
PHST- 1994/09/01 00:01 [medline]
PHST- 1994/09/01 00:00 [entrez]
AID - S0042682284714838 [pii]
AID - 10.1006/viro.1994.1483 [doi]
PST - ppublish
SO  - Virology. 1994 Sep;203(2):260-8. doi: 10.1006/viro.1994.1483.