PMID- 8054723
OWN - NLM
STAT- MEDLINE
DCOM- 19940912
LR  - 20190920
IS  - 0886-0440 (Print)
IS  - 0886-0440 (Linking)
VI  - 9
IP  - 3
DP  - 1994 May
TI  - Aortic valve replacement with cryopreserved allografts: mid-term results.
PG  - 292-7
AB  - OBJECTIVE: Analysis of the clinical and echocardiographic mid-term results 
      following aortic valve replacement (AVR) with cryopreserved allografts. DESIGN 
      AND SETTING: A cohort study in a tertiary care center. PATIENTS: Fifty patients 
      underwent allograft AVR during the years 1987 through 1992. There were 44 men and 
      6 women with a mean age of 47.6 +/- 12.2 years (range 22 to 72 years). 
      Indications for operation included: aortic stenosis (AS) 15 patients, aortic 
      regurgitation (AR) 24, and mixed 11. The etiology was: congenital 22, rheumatic 
      8, degenerative 5, senile calcific 4, malfunctioning aortic valve prosthesis 5, 
      and active endocarditis 6. OUTCOME MEASURES: Early mortality and morbidity; 
      mid-term survival, functional class, and valve related complications; and 
      two-dimensional Doppler echocardiography to assess valve structure and function. 
      RESULTS: Two patients (4%) died perioperatively of noncardiac or valve related 
      causes. Long-term follow-up ranged from 4 to 60 months (median 34 months), with 
      no late mortality, recurrence of endocarditis, or thromboembolic events. 
      Thirty-nine patients were in New York Heart Association (NYHA) Class I (83%) and 
      7 (15%) in Class II. Of these, echocardiogram showed trace or no AR in 42 (98%) 
      and 2+ AR in 1. One allograft was re-replaced with a mechanical valve due to 
      technical failure. One patient was in NYHA Class III with normal allograft 
      function and 4+ mitral regurgitation. CONCLUSIONS: Replacement of the aortic 
      valve by a cryopreserved allograft can be performed safely, and is particularly 
      useful in the setting of active endocarditis and failed prior prosthetic valve. 
      Mid-term clinical results and valve durability at 5 years are excellent.
FAU - Shapira, O M
AU  - Shapira OM
AD  - Department of Cardiothoracic Surgery, Boston University Medical Center, 
      University Hospital, Massachusetts 02118.
FAU - Shemin, R J
AU  - Shemin RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Card Surg
JT  - Journal of cardiac surgery
JID - 8908809
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Valve/diagnostic imaging/*transplantation
MH  - Aortic Valve Insufficiency/surgery
MH  - Aortic Valve Stenosis/surgery
MH  - Cohort Studies
MH  - *Cryopreservation
MH  - Echocardiography
MH  - Echocardiography, Doppler
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Reoperation
MH  - Retrospective Studies
MH  - Survival Rate
MH  - *Tissue Preservation
MH  - Transplantation, Homologous
EDAT- 1994/05/01 00:00
MHDA- 1994/05/01 00:01
CRDT- 1994/05/01 00:00
PHST- 1994/05/01 00:00 [pubmed]
PHST- 1994/05/01 00:01 [medline]
PHST- 1994/05/01 00:00 [entrez]
AID - 10.1111/j.1540-8191.1994.tb00847.x [doi]
PST - ppublish
SO  - J Card Surg. 1994 May;9(3):292-7. doi: 10.1111/j.1540-8191.1994.tb00847.x.